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Low Ki-67 Proliferation Index Is an Indicator of Poor Prognosis in Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Hee Eun | - |
dc.contributor.author | Kim, Min A. | - |
dc.contributor.author | Lee, Byung Lan | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.date.accessioned | 2012-05-31T02:40:26Z | - |
dc.date.available | 2012-05-31T02:40:26Z | - |
dc.date.issued | 2010-09-01 | - |
dc.identifier.citation | JOURNAL OF SURGICAL ONCOLOGY; Vol.102 3; 201-206 | ko_KR |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76658 | - |
dc.description.abstract | Background and Objectives: We designed this study to assess the biologic significance of Ki-67 proliferation index (PI) in gastric cancer. Methods: Gastric cancer tissue from 245 patients were immunostained for Ki-67. Ki-67 PI was defined as the percentage of tumor cells positive for Ki-67. In addition, we have previously evaluated the expressions of nine epithelial mesenchymal transition (EMT)-related proteins. The relationship between Ki-67 PI and clinicopathologic parameters, patient survival, and EMT data were sought. Results: Low Ki-67 PI was correlated with poorly differentiated histology (P = 0.034), an advanced T stage (P < 0.001), and lymph node metastasis (P = 0.011). Also, the low PI group was found to have a significantly worse prognosis than the high PI group (P = 0.003, log-rank test). Multivariate analysis revealed that Ki-67 PI remained as an independent prognostic factor (hazard ratio (95% CI) = 0.670 (0.450-0.999)). Furthermore, greater expressional changes of EMT-related proteins were found to be significantly associated with low Ki-67 PI (P = 0.025). Conclusions: These findings suggest that Ki-67 PI is an effective tool for predicting survival in gastric cancer. In addition, we found that an invasive property presented as EMT-related protein expressional changes was inversely correlated with a proliferative activity in gastric cancer. J. Surg. Oncol. 2010;102:201-206. (C) 2010 Wiley-Liss, Inc. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-LISS | ko_KR |
dc.subject | stomach neoplasms | ko_KR |
dc.subject | immunohistochemistry | ko_KR |
dc.subject | tissue array analysis | ko_KR |
dc.subject | survival analysis | ko_KR |
dc.title | Low Ki-67 Proliferation Index Is an Indicator of Poor Prognosis in Gastric Cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이희은 | - |
dc.contributor.AlternativeAuthor | 김민아 | - |
dc.contributor.AlternativeAuthor | 이병란 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.identifier.doi | 10.1002/jso.21583 | - |
dc.citation.journaltitle | JOURNAL OF SURGICAL ONCOLOGY | - |
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dc.description.tc | 2 | - |
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