Publications
Detailed Information
IL-12p35 Promotes Antibody-Induced Joint Inflammation by Activating NKT Cells and Suppressing TGF-beta
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yuna | - |
dc.contributor.author | Kim, Hye Sung | - |
dc.contributor.author | Ahn, Ji Ye | - |
dc.contributor.author | Yun, Daesun | - |
dc.contributor.author | Hong, Seokmann | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Kim, Ho Youn | - |
dc.contributor.author | Cho, Mi La | - |
dc.date.accessioned | 2012-05-31T04:24:36Z | - |
dc.date.available | 2012-05-31T04:24:36Z | - |
dc.date.issued | 2010-08-01 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY; Vol.185 3; 1476-1484 | ko_KR |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76661 | - |
dc.description.abstract | The functional role of IL-12 in rheumatoid arthritis is controversial. Moreover, whether IL-12 contributes to regulation of Ab-induced joint inflammation remains unclear. To address these issues, we explored the functional roles of IL-12 in Ab-induced arthritis using the K/BxN serum transfer model. IL-12p35(-/-) and IL-12R beta(-/-)(2) mice were resistant to the development of arthritis. Injection of K/BxN serum into IL-12p40-yellow fluorescence protein reporter (yet40) mice induced CD11b(+) cells, CD11c(+) cells, and Gr-1(+) granulocytes to produce IL-12p40 in the joints. The levels of IFN-gamma, IL-4, and IL-6 production were lower in joint tissues of IL-12p35(-/-) and IL-12R beta(-/-)(2) mice than in B6 mice, whereas levels of TGF-beta expression were higher. Administering IL-12p35(-/-) mice rIL-12 or IFN-gamma restored joint inflammation and suppressed TGF-beta production in joint tissues. Moreover, administering neutralizing anti-TGF-beta mAb enhanced joint inflammation. Among the immune cells that infiltrated joint tissues during Ab-induced arthritis, NKT cells expressed IL-12 beta(2) receptors. Furthermore, the adoptive transfer of splenocytes from B6 or Gr-1(+) granulocyte-depleted mice restored joint inflammation in IL-12R beta(-/-)(2) mice as much as in B6 mice, whereas splenocytes from J alpha 18(-/-) mice did not. These findings indicate that signals via IL-12 beta(2) receptors on NKT cells play a critical role in the development of Ab-induced arthritis. The IL-12p35/IFN-gamma axis promotes Ab-induced joint inflammation by activating NKT cells and suppressing TGF-beta, which may provide novel information for the development of new therapeutic strategies for the inhibition of rheumatoid arthritis. The Journal of Immunology, 2010, 185: 1476-1484. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | ko_KR |
dc.title | IL-12p35 Promotes Antibody-Induced Joint Inflammation by Activating NKT Cells and Suppressing TGF-beta | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박연아 | - |
dc.contributor.AlternativeAuthor | 김혜성 | - |
dc.contributor.AlternativeAuthor | 안지예 | - |
dc.contributor.AlternativeAuthor | 윤대선 | - |
dc.contributor.AlternativeAuthor | 조미라 | - |
dc.contributor.AlternativeAuthor | 홍석만 | - |
dc.contributor.AlternativeAuthor | 김호윤 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.identifier.doi | 10.4049/jimmunol.1000425 | - |
dc.citation.journaltitle | JOURNAL OF IMMUNOLOGY | - |
dc.description.citedreference | Shahrara S, 2009, J IMMUNOL, V182, P3884 | - |
dc.description.citedreference | Brennan FM, 2008, J CLIN INVEST, V118, P3537, DOI 10.1172/JCI36389 | - |
dc.description.citedreference | Hirota K, 2007, J EXP MED, V204, P41, DOI 10.1084/jem.20062259 | - |
dc.description.citedreference | Kim HY, 2006, J CLIN INVEST, V116, P2484, DOI 10.1172/JCI27219 | - |
dc.description.citedreference | Uhlig HH, 2006, IMMUNITY, V25, P309, DOI 10.1016/j.immuni.2006.05.017 | - |
dc.description.citedreference | Reinhardt RL, 2006, J IMMUNOL, V177, P1618 | - |
dc.description.citedreference | Koenders MI, 2006, J IMMUNOL, V176, P6262 | - |
dc.description.citedreference | Kim HY, 2005, J EXP MED, V201, P41, DOI 10.1084/jem.20041400 | - |
dc.description.citedreference | Gumperz JE, 2004, J LEUKOCYTE BIOL, V76, P307, DOI 10.1189/jlb.0104038 | - |
dc.description.citedreference | Murphy CA, 2003, J EXP MED, V198, P1951, DOI 10.1084/jem.20030896 | - |
dc.description.citedreference | Brigl M, 2003, NAT IMMUNOL, V4, P1230, DOI 10.1038/ni1002 | - |
dc.description.citedreference | Baxevanis CN, 2003, J IMMUNOL, V171, P2953 | - |
dc.description.citedreference | Bruhns P, 2003, IMMUNITY, V18, P573 | - |
dc.description.citedreference | Lubberts E, 2003, J IMMUNOL, V170, P2655 | - |
dc.description.citedreference | Finnegan A, 2002, J IMMUNOL, V169, P3345 | - |
dc.description.citedreference | Joosten LAB, 2002, ARTHRITIS RHEUM, V46, P1379, DOI 10.1002/art.10233 | - |
dc.description.citedreference | Peeva E, 2000, ARTHRITIS RHEUM, V43, P461 | - |
dc.description.citedreference | Butler DM, 1999, EUR J IMMUNOL, V29, P2205 | - |
dc.description.citedreference | Kitamura H, 1999, J EXP MED, V189, P1121 | - |
dc.description.citedreference | Kasama T, 1999, ARTHRITIS RHEUM, V42, P100 | - |
dc.description.citedreference | Gudmundsson G, 1998, J IMMUNOL, V161, P991 | - |
dc.description.citedreference | Matthys P, 1998, EUR J IMMUNOL, V28, P2143 | - |
dc.description.citedreference | Parks E, 1998, J IMMUNOL, V160, P4615 | - |
dc.description.citedreference | Malfait AM, 1998, CLIN EXP IMMUNOL, V111, P377 | - |
dc.description.citedreference | Bright JJ, 1998, J NEUROIMMUNOL, V82, P22 | - |
dc.description.citedreference | Joosten LAB, 1997, J IMMUNOL, V159, P4094 | - |
dc.description.citedreference | Kouskoff V, 1996, CELL, V87, P811 | - |
dc.description.tc | 4 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.