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TMPRSS2-ERG Gene Fusion and Clinicopathologic Characteristics of Korean Prostate Cancer Patients
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyoungbun | - |
dc.contributor.author | Chae, Ji Youn | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Ku, Ja Hyeon | - |
dc.contributor.author | Moon, Kyung Chul | - |
dc.date.accessioned | 2012-05-31T04:42:17Z | - |
dc.date.available | 2012-05-31T04:42:17Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | UROLOGY; Vol.76 5; 1268.e7–1268.e13 | ko_KR |
dc.identifier.issn | 0090-4295 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76665 | - |
dc.description.abstract | OBJECTIVES To survey the status of TMPRSS2-ERG fusion in Korean prostate cancer patients, we assessed the differences in clinicopathologic characteristics and biochemical recurrence according to TMPRSS2-ERG fusion status. METHODS The incidence of the TMPRSS2-ERG fusion gene was evaluated via fluorescence in situ hybridization (FISH) using ERG break-apart probes in 254 prostate cancer tissues resected by radical prostatectomy, and analyses of clinicopathologic parameters and biochemical recurrence were conducted. RESULTS The fusion rate of the TMPRSS2-ERG gene was 20.9% (53/254). TMPRSS2-ERG gene fusion was identified more frequently in patients with low Gleason grade (primary Gleason pattern <= 3 or sum of Gleason score <= 7, P = .015 and .027). Patients with large cribriform glands in Gleason pattern 4 harbored a rare TMPRSS2-ERG fusion gene compared with patients without large cribriform glands (P = .027). The incidence of biochemical recurrence did not differ according to TMPRSS2-ERG fusion gene status (P = .598). CONCLUSIONS ERG gene aberration did not correlate with biochemical recurrence of prostate cancers in Korean patients. Lower Gleason grade demonstrated higher rates of TMPRSS2-ERG fusion compared with high-grade tumors, including those demonstrating a large cribriform glands pattern. Prostate cancer with large cribriform glands revealed rare TMPRSS2-ERG gene fusion. UROLOGY 76: 1268.e7-1268.e13, 2010. (C) 2010 Elsevier Inc. | ko_KR |
dc.description.sponsorship | This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of
Health and Welfare, Republic of Korea (A080239). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.title | TMPRSS2-ERG Gene Fusion and Clinicopathologic Characteristics of Korean Prostate Cancer Patients | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이경분 | - |
dc.contributor.AlternativeAuthor | 채지윤 | - |
dc.contributor.AlternativeAuthor | 곽철 | - |
dc.contributor.AlternativeAuthor | 구자현 | - |
dc.contributor.AlternativeAuthor | 문경철 | - |
dc.identifier.doi | 10.1016/j.urology.2010.06.010 | - |
dc.citation.journaltitle | UROLOGY | - |
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dc.description.tc | 0 | - |
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