Browse

T Cell Ig Domain and Mucin Domain 1 Engagement on Invariant NKT Cells in the Presence of TCR Stimulation Enhances IL-4 Production but Inhibits IFN-gamma Production

DC Field Value Language
dc.contributor.authorKim, Hye Sung-
dc.contributor.authorKim, Hyun Soo-
dc.contributor.authorLee, Chang Woo-
dc.contributor.authorChung, Doo Hyun-
dc.date.accessioned2012-05-31T05:53:40Z-
dc.date.available2012-05-31T05:53:40Z-
dc.date.issued2010-04-15-
dc.identifier.citationJOURNAL OF IMMUNOLOGY; Vol.184 8; 4095-4106ko_KR
dc.identifier.issn0022-1767-
dc.identifier.urihttps://hdl.handle.net/10371/76679-
dc.description.abstractThe T cell Ig domain and mucin domain (TIM)1 protein expressed on the surface of Th2 cells regulates the immune response by modulating cytokine production. However, the functional roles of TIM1 have not been examined in NKT cells. Therefore, we investigated the immunologic effects of TIM1 on NKT cells. We found that mouse NK1.1(+)TCR-beta(+), alpha-galactosyl ceramide/CD1d dimer(+) NKT, and NKT hybridoma (DN32.D3) cells constitutively express TIM1 and TIM4 on their surface. Engagement of TIM1 on NKT cells by any of several anti-TIM1 mAbs suppressed the production of IFN-gamma in the presence of TCR stimulation in vitro and in vivo, whereas the effects of such engagement on Th2 cytokine production by the NKT cells varied with the particular anti-TIM1 Ab clone. Moreover, in DN32.D3 TIM4-knockdown NKT hybridoma cells, TIM1 engagement by rTIM1 or TIM4 enhanced IL-4 production while inhibiting IFN-gamma production in the presence of alpha-galactosyl ceramide stimulation. TIM1 engagement increased GATA-3 expression but reduced T-bet expression in NKT cells in the presence of TCR engagement. The adoptive transfer of NKT cells preincubated with anti-TIM1 mAbs into J alpha 18(-/-) mice aggravated bleomycin-induced pulmonary fibrosis by suppressing IFN-gamma production. Taken together, these results suggest that TIM1 costimulation on NKT cells enhances the cellular production of IL-4 while inhibiting the production of IFN-gamma. Thus, as a differential regulator of the immune response, TIM1 on NKT cells may be a useful therapeutic target for immune diseases. The Journal of Immunology, 2010, 184: 4095-4106.ko_KR
dc.language.isoenko_KR
dc.publisherAMER ASSOC IMMUNOLOGISTSko_KR
dc.titleT Cell Ig Domain and Mucin Domain 1 Engagement on Invariant NKT Cells in the Presence of TCR Stimulation Enhances IL-4 Production but Inhibits IFN-gamma Productionko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김혜성-
dc.contributor.AlternativeAuthor김현수-
dc.contributor.AlternativeAuthor이창우-
dc.contributor.AlternativeAuthor정두현-
dc.identifier.doi10.4049/jimmunol.0901991-
dc.citation.journaltitleJOURNAL OF IMMUNOLOGY-
dc.description.citedreferenceKosaka H, 2008, NAT MED, V14, P437, DOI 10.1038/nm1733-
dc.description.citedreferenceRodriguez-Manzanet R, 2008, J IMMUNOL, V180, P4706-
dc.description.citedreferenceDegauque N, 2008, J CLIN INVEST, V118, P735, DOI 10.1172/JCI32562-
dc.description.citedreferenceUeno T, 2008, J CLIN INVEST, V118, P742, DOI 10.1172/JCI32451-
dc.description.citedreferenceKobayashi N, 2007, IMMUNITY, V27, P927, DOI 10.1016/j.immuni.2007.11.011-
dc.description.citedreferenceKim JH, 2007, J IMMUNOL, V179, P6579-
dc.description.citedreferenceNakae S, 2007, BLOOD, V110, P2565, DOI 10.1182/blood-2006-11-058800-
dc.description.citedreferenceXiao S, 2007, J EXP MED, V204, P1691, DOI 10.1084/jem.20062498-
dc.description.citedreferenceNakae S, 2007, J LEUKOCYTE BIOL, V81, P1258, DOI 10.1186/jlb.1006610-
dc.description.citedreferenceSantiago C, 2007, IMMUNITY, V26, P299, DOI 10.1016/j.immuni.2007.01.014-
dc.description.citedreferenceBendelac A, 2007, ANNU REV IMMUNOL, V25, P297, DOI 10.1146/annurev.immunol.25.022106.141711-
dc.description.citedreferenceSIZING ID, 2007, J IMMUNOL, V178, P2249-
dc.description.citedreferenceHwang SJ, 2006, J IMMUNOL, V177, P5258-
dc.description.citedreferenceKim HY, 2006, J CLIN INVEST, V116, P2484, DOI 10.1172/JCI27219-
dc.description.citedreferenceKim HJ, 2006, IMMUNOLOGY, V118, P101, DOI 10.1111/j.1365-2567.2006.02346.x-
dc.description.citedreferenceKim HJ, 2006, J IMMUNOL, V176, P3507-
dc.description.citedreferenceMesri M, 2006, INT IMMUNOL, V18, P473, DOI 10.1093/intimm/dxh388-
dc.description.citedreferenceEncinas JA, 2005, J ALLERGY CLIN IMMUN, V116, P1343, DOI 10.1016/j.jaci.2005.08.031-
dc.description.citedreferenceKim JH, 2005, AM J PATHOL, V167, P1231-
dc.description.citedreferenceUmetsu SE, 2005, NAT IMMUNOL, V6, P447, DOI 10.1038/ni1186-
dc.description.citedreferenceMeyers JH, 2005, NAT IMMUNOL, V6, P455, DOI 10.1038/ni1185-
dc.description.citedreferenceKaneda H, 2005, BIOCHEM BIOPH RES CO, V327, P201, DOI 10.1016/j.bbrc.2004.12.004-
dc.description.citedreferenceKim HY, 2005, J EXP MED, V201, P41, DOI 10.1084/jem.20041400-
dc.description.citedreferenceHoebe K, 2004, NAT IMMUNOL, V5, P971, DOI 10.1038/ni1004-971-
dc.description.citedreferenceLisbonne M, 2003, J IMMUNOL, V171, P1637-
dc.description.citedreferenceSilberstein E, 2003, J VIROL, V77, P8765, DOI 10.1128/JVI.77.16.8765-8774.2003-
dc.description.citedreferenceKuchroo VK, 2003, NAT REV IMMUNOL, V3, P454, DOI 10.1038/nri1111-
dc.description.citedreferenceAkbari O, 2003, NAT MED, V9, P582, DOI 10.1038/nm851-
dc.description.citedreferenceTaniguchi M, 2003, ANNU REV IMMUNOL, V21, P483, DOI 10.1146/annurev.ummunol.21.120601.141057-
dc.description.citedreferenceGonzalez-Aseguinolaza G, 2002, J EXP MED, V195, P617, DOI 10.1084/jem.20011889-
dc.description.citedreferenceSharif S, 2001, NAT MED, V7, P1057-
dc.description.citedreferenceKeane MP, 2001, AM J PHYSIOL-LUNG C, V281, pL92-
dc.description.citedreferenceHayakawa Y, 2001, J IMMUNOL, V166, P6012-
dc.description.citedreferenceSeino K, 2001, P NATL ACAD SCI USA, V98, P2577-
dc.description.citedreferenceMoore BB, 2000, J IMMUNOL, V165, P4032-
dc.description.citedreferenceSzabo SJ, 2000, CELL, V100, P655-
dc.description.citedreferenceKorsgren M, 1999, J EXP MED, V189, P553-
dc.description.citedreferenceBurdin N, 1998, J IMMUNOL, V161, P3271-
dc.description.citedreferenceCui JQ, 1997, SCIENCE, V278, P1623-
dc.description.citedreferenceChen HJ, 1997, J IMMUNOL, V159, P2240-
dc.description.citedreferenceZheng WP, 1997, CELL, V89, P587-
dc.description.citedreferenceBendelac A, 1997, ANNU REV IMMUNOL, V15, P535-
dc.description.citedreferenceBENDELAC A, 1995, SCIENCE, V269, P185-
dc.description.citedreferenceLANTZ O, 1994, J EXP MED, V180, P1097-
dc.description.tc7-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse