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Hepatocellular Carcinoma with Immature T-Cell (T-lymphoblastic) Proliferation

Cited 14 time in Web of Science Cited 11 time in Scopus
Authors
Eun, Shin; Jeon, Youn Kyung; Jang, Ja June
Issue Date
2010-02
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 2; 309-312
Keywords
LymphocytesTumor-Infiltratingindolent T-lymphoblastic proliferationImmunohistochemistryHepatocellularCarcinoma
Abstract
Indolent T-lymphoblastic proliferation has been rarely reported in the upper aerodigestive tract. The lymphoid cells associated with this condition have the morphological and phenotypical features of immature thymocytes. However, their pathogenesis and biology are unknown. We present an unusual type of tumor infiltrating lymphocytes in a case with hepatocellular carcinoma, presumed to be a T-lymphoblastic proliferation. A 58-yr-old female patient presented with indigestion and a palpable epigastric mass. The abdominal computed tomography revealed a mass in the S6 region of the liver. A hepatic segmentectomy was performed. Microscopic examination showed dense isolated nests of monomorphic lymphoid cells within the tumor. Immunohistochemically, the lymphoid cells were positive for CD3, terminal deoxymucleotide transferase (TdT) and CD1a. In addition, they showed dual expression of CD4 and CD8. The polymerase chain reaction used to examine the T-cell antigen receptor gamma gene rearrangement showed polyclonal T-cell proliferation. This is the second case of hepatocellular carcinoma combined with indolent T-lymphoblastic proliferation identified by an unusual tumor infiltrating lymphocytes.
ISSN
1011-8934
Language
English
URI
https://hdl.handle.net/10371/76688
DOI
https://doi.org/10.3346/jkms.2010.25.2.309
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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