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Evaluation of the Hemodynamics of a Tissue-engineered Hybrid Graft

Cited 2 time in Web of Science Cited 3 time in Scopus
Issue Date
2010-01
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
ARTIFICIAL ORGANS; Vol.34 1; E17-E21
Keywords
Blood dynamicsBiocompatible materialsVascular graftTissue regenerationIn vivo
Abstract
We evaluated the hemodynamics of tissue-engineered hybrid graft in vivo. The hybrid expanded polytetrafluoroethylene (ePTFE) scaffold was fabricated by coating the ePTFE graft with poly (lactide-co-glycolide) (PLGA) solution. This scaffold was turned into an engineered hybrid graft by culturing smooth muscle cells on its surface. Both the ePTFE (n = 6) and the engineered hybrid grafts (n = 8) were implanted in the carotid arteries of mongrel dogs. The length of intima in the engineered hybrid graft was greater than the ePTFE. The neoarterial thickness in the engineered hybrid group was greater, and the foreign body reaction was more severe. We compared the hemodynamics (diameter, flow rate, pulsatile index, mean velocity, shear stress, resistance index, and systolic/diastolic ratio) of the native arteries in the distal anastmosis. The shear rate in the engineered hybrid group was higher immediately after implantation, and the resistance index was lower, but there was no significant difference after 4 weeks. The engineered grafts demonstrated similar hemodynamics with the ePTFE grafts after 4 weeks implantation.
ISSN
0160-564X
Language
English
URI
https://hdl.handle.net/10371/76715
DOI
https://doi.org/10.1111/j.1525-1594.2009.00874.x
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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