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Effects of TGF-beta on Podocyte Growth and Disease Progression in Proliferative Podocytopathies

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dc.contributor.authorLee, Hyun Soon-
dc.contributor.authorSong, Chi Young-
dc.date.accessioned2012-06-01T08:18:01Z-
dc.date.available2012-06-01T08:18:01Z-
dc.date.issued2010-
dc.identifier.citationKIDNEY & BLOOD PRESSURE RESEARCH; Vol.33 1; 24-29ko_KR
dc.identifier.issn1420-4096-
dc.identifier.urihttps://hdl.handle.net/10371/76729-
dc.description.abstractInjured podocytes proliferate in cellular focal segmental glomerulosclerosis (FSGS), collapsing FSGS and crescentic glomerulonephritis, where TGF-beta(1) is overexpressed in hyperplastic podocytes. Yet effects of podocyte TGF-beta on podocyte growth and development of glomerulosclerosis have not been clearly defined. TGF-beta activates Smads, Ras/extracellular signal-regulated kinase (ERK) and phosphatidyl inositol-3-kinase (PI3K) pathways in podocytes, of which the major TGF-beta/Smad signaling pathway appears to override the minor TGF-beta-induced Ras/ERK/PI3K pathways. We provide evidence that increased TGF-beta/Smad signaling activity by hyperplastic podocytes may lead to mesangial cell matrix overproduction and eventually to podocyte apoptosis and/or detachment, culminating in the development of glomerulosclerosis. In this regard, TGF-beta, which is overexpressed by hyperplastic podocytes, may play an important role for the cellular and collapsing variants of FSGS to evolve into the classic FSGS pattern. In contrast, podocyte proliferation that is induced by Ras/ERK signaling activity in proliferative podocyte diseases seems to be mostly independent of TGF- beta(1) activity. Collectively, these data bring new insights into our understanding of the overexpression of TGF-beta in hyperplastic podocytes in progressive glomerular diseases. Copyright (C) 2010 S. Karger AG, Baselko_KR
dc.language.isoenko_KR
dc.publisherKARGERko_KR
dc.subjectCellular FSGSko_KR
dc.subjectSmadsko_KR
dc.subjectRas/ERKko_KR
dc.subjectPodocyte TGF-betako_KR
dc.subjectCollapsing FSGSko_KR
dc.subjectCrescentic glomerulonephritisko_KR
dc.titleEffects of TGF-beta on Podocyte Growth and Disease Progression in Proliferative Podocytopathiesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이현순-
dc.contributor.AlternativeAuthor송지영-
dc.identifier.doi10.1159/000285844-
dc.citation.journaltitleKIDNEY & BLOOD PRESSURE RESEARCH-
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