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Effects of TGF-beta on Podocyte Growth and Disease Progression in Proliferative Podocytopathies
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Soon | - |
dc.contributor.author | Song, Chi Young | - |
dc.date.accessioned | 2012-06-01T08:18:01Z | - |
dc.date.available | 2012-06-01T08:18:01Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | KIDNEY & BLOOD PRESSURE RESEARCH; Vol.33 1; 24-29 | ko_KR |
dc.identifier.issn | 1420-4096 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76729 | - |
dc.description.abstract | Injured podocytes proliferate in cellular focal segmental glomerulosclerosis (FSGS), collapsing FSGS and crescentic glomerulonephritis, where TGF-beta(1) is overexpressed in hyperplastic podocytes. Yet effects of podocyte TGF-beta on podocyte growth and development of glomerulosclerosis have not been clearly defined. TGF-beta activates Smads, Ras/extracellular signal-regulated kinase (ERK) and phosphatidyl inositol-3-kinase (PI3K) pathways in podocytes, of which the major TGF-beta/Smad signaling pathway appears to override the minor TGF-beta-induced Ras/ERK/PI3K pathways. We provide evidence that increased TGF-beta/Smad signaling activity by hyperplastic podocytes may lead to mesangial cell matrix overproduction and eventually to podocyte apoptosis and/or detachment, culminating in the development of glomerulosclerosis. In this regard, TGF-beta, which is overexpressed by hyperplastic podocytes, may play an important role for the cellular and collapsing variants of FSGS to evolve into the classic FSGS pattern. In contrast, podocyte proliferation that is induced by Ras/ERK signaling activity in proliferative podocyte diseases seems to be mostly independent of TGF- beta(1) activity. Collectively, these data bring new insights into our understanding of the overexpression of TGF-beta in hyperplastic podocytes in progressive glomerular diseases. Copyright (C) 2010 S. Karger AG, Basel | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KARGER | ko_KR |
dc.subject | Cellular FSGS | ko_KR |
dc.subject | Smads | ko_KR |
dc.subject | Ras/ERK | ko_KR |
dc.subject | Podocyte TGF-beta | ko_KR |
dc.subject | Collapsing FSGS | ko_KR |
dc.subject | Crescentic glomerulonephritis | ko_KR |
dc.title | Effects of TGF-beta on Podocyte Growth and Disease Progression in Proliferative Podocytopathies | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이현순 | - |
dc.contributor.AlternativeAuthor | 송지영 | - |
dc.identifier.doi | 10.1159/000285844 | - |
dc.citation.journaltitle | KIDNEY & BLOOD PRESSURE RESEARCH | - |
dc.description.citedreference | Xavier S, 2009, J AM SOC NEPHROL, V20, P2127, DOI 10.1681/ASN.2008070806 | - |
dc.description.citedreference | Lee HS, 2009, HISTOL HISTOPATHOL, V24, P901 | - |
dc.description.citedreference | Lee EY, 2009, AM J PHYSIOL-RENAL, V297, pF85, DOI 10.1152/ajprenal.90642.2008 | - |
dc.description.citedreference | Appel D, 2009, J AM SOC NEPHROL, V20, P333, DOI 10.1681/ASN.2008070795 | - |
dc.description.citedreference | Barisoni L, 2009, ARCH PATHOL LAB MED, V133, P201 | - |
dc.description.citedreference | Chan KT, 2009, KIDNEY INT, V75, P366, DOI 10.1038/ki.2008.625 | - |
dc.description.citedreference | Perazella MA, 2008, KIDNEY INT, V74, P1385, DOI 10.1038/ki.2008.356 | - |
dc.description.citedreference | Yamada S, 2008, CLIN EXP NEPHROL, V12, P509, DOI 10.1007/s10157-008-0088-8 | - |
dc.description.citedreference | Nasr SH, 2008, CLIN J AM SOC NEPHRO, V3, P1282, DOI 10.2215/CJN.00740208 | - |
dc.description.citedreference | Korgaonkar SN, 2008, J AM SOC NEPHROL, V19, P877, DOI 10.1681/ASN2007050629 | - |
dc.description.citedreference | Thorner PS, 2008, J AM SOC NEPHROL, V19, P495, DOI 10.1681/ASN.2006101115 | - |
dc.description.citedreference | Barisoni L, 2007, CURR OPIN NEPHROL HY, V16, P192 | - |
dc.description.citedreference | Song CY, 2007, KIDNEY INT, V71, P882, DOI 10.1038/sj.ki.5002149 | - |
dc.description.citedreference | Stokes MB, 2006, KIDNEY INT, V70, P1783, DOI 10.1038//sj.ki.5001903 | - |
dc.description.citedreference | Ding M, 2006, NAT MED, V12, P1081, DOI 10.1038/nm1460 | - |
dc.description.citedreference | Shimizu M, 2006, NEPHROL DIAL TRANSPL, V21, P2380, DOI 10.1093/ndt/gfl243 | - |
dc.description.citedreference | Kwoh C, 2006, ANNU REV PATHOL-MECH, V1, P349, DOI 10.1146/annurev.pathol.1.110304.100119 | - |
dc.description.citedreference | Wada T, 2005, KIDNEY INT, V68, P1618 | - |
dc.description.citedreference | Bariety J, 2005, KIDNEY INT, V68, P1109 | - |
dc.description.citedreference | Wolf G, 2005, DIABETES, V54, P1626 | - |
dc.description.citedreference | Hellwig-Burgel T, 2005, J INTERF CYTOK RES, V25, P297 | - |
dc.description.citedreference | Griffin SV, 2005, KIDNEY INT, V67, P977 | - |
dc.description.citedreference | Kriz W, 2005, KIDNEY INT, V67, P404 | - |
dc.description.citedreference | Liu SY, 2005, CELL PHYSIOL BIOCHEM, V16, P207 | - |
dc.description.citedreference | He JCJ, 2004, J CLIN INVEST, V114, P643, DOI 10.1172/JCI200421004 | - |
dc.description.citedreference | Schiffer M, 2004, J BIOL CHEM, V279, P37004, DOI 10.1074/jbc.M403534200 | - |
dc.description.citedreference | Chun MJ, 2004, J AM SOC NEPHROL, V15, P2169, DOI 10.1097/01.ASN.0000135051.62500.97 | - |
dc.description.citedreference | Masaki T, 2004, J AM SOC NEPHROL, V15, P1835, DOI 10.1097/01.ASN.0000130623.66271.67 | - |
dc.description.citedreference | Ijichi H, 2004, ONCOGENE, V23, P1043, DOI 10.1038/sj.onc.1207222 | - |
dc.description.citedreference | D`Agati VD, 2004, AM J KIDNEY DIS, V43, P368, DOI 10.1053/j.ajkd.2003.10.024 | - |
dc.description.citedreference | Davies CC, 2004, J BIOL CHEM, V279, P1010, DOI 10.1074/jbc.M303820200 | - |
dc.description.citedreference | Wang S, 2004, AM J KIDNEY DIS, V43, P19, DOI 10.1053/j.ajkd.2003.09.010 | - |
dc.description.citedreference | PETTERMANN A, 2004, AM J PATHOL, V164, P1417 | - |
dc.description.citedreference | Moeller MJ, 2004, J AM SOC NEPHROL, V15, P61, DOI 10.1097/01.ASN.0000102468.37809.C6 | - |
dc.description.citedreference | Kim JH, 2003, KIDNEY INT, V64, P1715 | - |
dc.description.citedreference | Patek CE, 2003, HUM MOL GENET, V12, P2379, DOI 10.1093/hmg/ddg240 | - |
dc.description.citedreference | Johnson GL, 2002, SCIENCE, V298, P1911 | - |
dc.description.citedreference | Mundel P, 2002, J AM SOC NEPHROL, V13, P3005, DOI 10.1097/01.ASN.0000039661.06947.FD | - |
dc.description.citedreference | Abbate M, 2002, AM J PATHOL, V161, P2179 | - |
dc.description.citedreference | Schiffer M, 2002, J AM SOC NEPHROL, V13, P2657, DOI 10.1097/01.ASN.0000033276.06451.50 | - |
dc.description.citedreference | Kim HW, 2002, NEPHROLOGY, V7, pS131 | - |
dc.description.citedreference | Mazzucco G, 2002, AM J KIDNEY DIS, V39, P713, DOI 10.1053/ajkd.2002.31988 | - |
dc.description.citedreference | Ammit AJ, 2001, J APPL PHYSIOL, V91, P1431 | - |
dc.description.citedreference | Schiffer M, 2001, J CLIN INVEST, V108, P807 | - |
dc.description.citedreference | Bariety J, 2001, J AM SOC NEPHROL, V12, P261 | - |
dc.description.citedreference | Massague J, 2000, CELL, V103, P295, DOI 10.1016/S0092-8674(00)00121-5 | - |
dc.description.citedreference | Pardali K, 2000, J BIOL CHEM, V275, P29244 | - |
dc.description.citedreference | Barisoni L, 2000, KIDNEY INT, V58, P137 | - |
dc.description.citedreference | Massague J, 2000, EMBO J, V19, P1745 | - |
dc.description.citedreference | Massague J, 2000, GENE DEV, V14, P627 | - |
dc.description.citedreference | Schwartz MM, 1999, J AM SOC NEPHROL, V10, P1900 | - |
dc.description.citedreference | Kivinen L, 1999, CELL GROWTH DIFFER, V10, P621 | - |
dc.description.citedreference | Kretzschmar M, 1999, GENE DEV, V13, P804 | - |
dc.description.citedreference | Stokes MB, 1999, AM J KIDNEY DIS, V33, P658 | - |
dc.description.citedreference | Barisoni L, 1999, J AM SOC NEPHROL, V10, P51 | - |
dc.description.citedreference | Bariety J, 1998, KIDNEY INT, V53, P918 | - |
dc.description.citedreference | Arrizabalaga P, 1998, AM J NEPHROL, V18, P77 | - |
dc.description.citedreference | Tse WY, 1997, NEPHROL DIAL TRANSPL, V12, P1017 | - |
dc.description.citedreference | Hartsough MT, 1996, J BIOL CHEM, V271, P22368 | - |
dc.description.citedreference | Kriz W, 1996, NEPHROL DIAL TRANSPL, V11, P1738 | - |
dc.description.citedreference | Kopp JB, 1996, LAB INVEST, V74, P991 | - |
dc.description.citedreference | SANDERSON N, 1995, P NATL ACAD SCI USA, V92, P2572 | - |
dc.description.citedreference | DETWILER RK, 1994, KIDNEY INT, V45, P1416 | - |
dc.description.citedreference | HUPPES W, 1988, J PATHOL, V154, P187 | - |
dc.description.citedreference | WHITWORTH JA, 1978, CLIN NEPHROL, V9, P229 | - |
dc.description.tc | 9 | - |
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