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신경신호 측정을 위한 SPR(표면플라즈몬공명) 시스템 개발
Development of Surface Plasmon Resonance(SPR) system for detecting neural signals

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Authors
김신애; 박형원; 김성준
Issue Date
2007-05-11
Publisher
대한의용생체공학회 = The Korean Society of Medical & Biological Engineering
Citation
제35회 대한의용생체공학회 춘계학술대회, 전북대학교, 2007년 5월 11-12일
Abstract
This study aims to develop a new effective
extracellular recording system for detecting
neural signal using Surface Plasmon Resonance
(SPR). The SPR can directly detect
electrochemical signals at the metal-electrolyte
interface. In addition, this method has no time
limit in measurement and no artifact noise during
electrical stimulation compared with conventional
electrophysiological methods. However, the low
sensitivity of SPR has been known as a problem
for detecting a subtle ionic changes like action
potentials. To overcome this problem, we
improved several parts of a conventional SPR
system; i) introduction of a multi-cell
photo-detector with a mask, ii) introduction of a
ultra-low noise laser diode, iii) electrical
shielding of the whole optic system using a
custom-made faraday cage. Consequently, evoked
Compound Action Potentials (CAPS) from rat
sciatic nerves were successfully recorded. These
recordings are the first time of detecting neural
signal using SPR biosensor. These data indicate
that the SPR system can be used as a valuable
tool for the study of neural networks.
Language
Korean
URI
http://hdl.handle.net/10371/7674
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Others_전기·정보공학부
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