S-Space College of Medicine/School of Medicine (의과대학/대학원) Obstetrics & Gynecology (산부인과전공) Journal Papers (저널논문_산부인과학전공)
The role of serum CA-125 levels in early-stage epithelial ovarian cancer on preoperative CT and MRI
- Kim, H. S.; Kim, J. W.; Cho, J. Y.; Chung, H. H.; Song, Y. S.; Kang, S. B.; Kim, S. H.; Park, N. H.
- Issue Date
- ELSEVIER SCI LTD
- EJSO; Vol.35 8; 870-876
- Background: We sought to identify the role of serum CA-125 levels in early-stage epithelial ovarian cancer (EOC) on preoperative CT and MRI. Methods: Clinical data of 101 patients with early-stage EOC on preoperative CT and MRI were collected between January 2000 and December 2007. Clinical stage I (n = 59) was defined as tumor limited to the ovaries with or without ascites, whereas clinical stage II (n = 42) was defined as tumor within the pelvis with or without ascites. The primary endpoint was to investigate the efficacy of serum CA-125 levels for the prediction of advanced-stage disease, and secondary endpoints were to evaluate the accuracy of preoperative CT and MRI, and to examine the role of serum CA-125 levels as a prognostic factor for survival. Results: The results of preoperative CT and MRI were concordant with no peritoneal implants outside the pelvis in 50/101 (50%) and no lymph node metastasis in 71/101 (70%) patients. The receiver operating characteristic curves showed that best cut-off values of serum CA-125 levels were 320 U/ml (71% sensitivity, 84% specificity) and 5 10 U/ml (67% sensitivity, 80% specificity) for the prediction of peritoneal implants outside the pelvis and lymph node metastasis. The serum CA-125 level (>= 320 U/ml) was a significant factor for the prediction of advanced-stage disease (adjusted OR, 7.43: 95% CI, 2.39-23.04). However, it was not an independent prognostic factor for survival. Conclusions: Serum CA-125 levels may be very useful for the prediction of advanced-stage disease in early-stage EOC on preoperative CT and MRI. (C) 2009 Elsevier Ltd. All rights reserved.
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