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The importance of intra-amniotic inflammation in the subsequent development of atypical chronic lung disease
DC Field | Value | Language |
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dc.contributor.author | Lee, Joonho | - |
dc.contributor.author | Oh, Kyung Joon | - |
dc.contributor.author | Yang, Hye Jin | - |
dc.contributor.author | Park, Joong Shin | - |
dc.contributor.author | Yoon, Bo Hyun | - |
dc.contributor.author | Romero, Roberto | - |
dc.date.accessioned | 2012-06-04T02:30:58Z | - |
dc.date.available | 2012-06-04T02:30:58Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE; Vol.22 10; 917-923 | ko_KR |
dc.identifier.issn | 1476-7058 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76760 | - |
dc.description.abstract | Objective. To examine whether the intra-amniotic inflammation is a risk factor for the development of atypical chronic lung disease (CLD). Study design. A retrospective cohort study was undertaken in 72 patients who delivered preterm neonates (gestational age: 24-32 weeks) within 5 days of amniocentesis and whose neonates subsequently developed CLD. Atypical CLD was defined as CLD without respiratory distress syndrome (RDS). Intra-amniotic inflammation was defined as an elevated amniotic fluid (AF) concentration of matrix metalloproteinase-8 (MMP-8) (>23 ng/ml). Results. (1) Atypical CLD was identified in 54.2% (39/72) of cases with CLD; (2) there were no significant differences in the median gestational age at birth and the rate of antenatal corticosteroid use between infants with atypical CLD and CLD with RDS; (3) preterm newborns with atypical CLD had a significantly higher median AF MMP-8 concentration (median 373.1 ng/ml vs. 8.6 ng/ml, p=0.003) and median AF white blood cell count (median 450.0/mm(3) vs. 5.5/mm(3), p=0.009), and a higher rate of intra-amniotic inflammation (74.4% vs. 45.5%, p=0.012) than those with CLD with RDS. Conclusion. Intra-amniotic inflammation confers a greater risk for atypical CLD than for typical CLD with initial RDS. This novel observation strengthens the importance of prenatal inflammation as a mechanism of lung injury. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | TAYLOR & FRANCIS LTD | ko_KR |
dc.subject | Amniotic fluid matrix metalloproteinase-8 | ko_KR |
dc.subject | atypical chronic lung disease | ko_KR |
dc.subject | intra-amniotic inflammation | ko_KR |
dc.title | The importance of intra-amniotic inflammation in the subsequent development of atypical chronic lung disease | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이준호 | - |
dc.contributor.AlternativeAuthor | 오경준 | - |
dc.contributor.AlternativeAuthor | 양혜진 | - |
dc.contributor.AlternativeAuthor | 박중신 | - |
dc.contributor.AlternativeAuthor | 윤보현 | - |
dc.identifier.doi | 10.1080/14767050902994705 | - |
dc.citation.journaltitle | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | - |
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dc.description.tc | 4 | - |
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