Browse

The Relationship Between COL3A1 Exon 31 Polymorphism and Pelvic Organ Prolapse

Cited 15 time in Web of Science Cited 17 time in Scopus
Authors
Jeon, Myung Jae; Chung, Sue Min; Choi, Jong Rak; Jung, Hyun Joo; Bai, Sang Wook; Kim, Sei Kwang
Issue Date
2009-03
Publisher
ELSEVIER SCIENCE INC
Citation
JOURNAL OF UROLOGY; Vol.181 3; 1213-1216
Keywords
prolapseriskpolymorphism, geneticgene expressionpostmenopause
Abstract
Purpose: We investigated the role of COL3A1 exon 31 polymorphism (a single base substitution from guanine to adenine at +2092), resulting in the replacement of alanine with threonine at the 698th amino acid of COL3A1, in the pathogenesis of pelvic organ prolapse. Materials and Methods: A total of 72 postmenopausal Korean women who were not on hormonal replacement therapy and who had a history of vaginal childbirth were enrolled in this study. The patient group consisted of 36 women diagnosed with stage II or greater pelvic organ prolapse irrespective of urodynamic stress incontinence. The control group consisted of 36 healthy volunteers with pelvic organ prolapse quantification system stage 0 or I disease without urodynamic stress incontinence. After extracting the genomic DNA from peripheral blood leukocytes the polymorphism of exon 31 of COL3A1 was typed by restriction fragment length polymorphism (Alu I restriction fragment length polymorphism) and confirmed by direct sequencing. Results: Frequency of the G allele was significantly higher inpatients with pelvic organ prolapse than in controls (0.8 vs 0.6, p = 0.002). In women with the G allele the OR for pelvic organ prolapse was 3.2 (95% CI 1.4-7.3). Conclusions: COL3A1 exon 31 polymorphism may have a role in determining the risk of pelvic organ prolapse in women with risk factors such as aging, vaginal childbirth and hypoestrogenism.
ISSN
0022-5347
Language
English
URI
http://hdl.handle.net/10371/76775
DOI
https://doi.org/10.1016/j.juro.2008.11.027
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse