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Tissue Expression of Manganese Superoxide Dismutase Is a Candidate Prognostic Marker for Glioblastoma

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dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorJung, Ji Hye-
dc.contributor.authorMoon, Min Jeong-
dc.contributor.authorKim, Young-Yim-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorPaek, Sun Ha-
dc.contributor.authorJung, Hee-Won-
dc.contributor.authorCho, Byung-Kyu-
dc.contributor.authorKim, Dong Gyu-
dc.contributor.authorKim, Chae-Yong-
dc.contributor.authorKim, Jin Hyun-
dc.date.accessioned2012-06-04T05:12:27Z-
dc.date.available2012-06-04T05:12:27Z-
dc.date.issued2009-
dc.identifier.citationONCOLOGY; Vol.77 03월 04일; 178-181ko_KR
dc.identifier.issn0030-2414-
dc.identifier.urihttps://hdl.handle.net/10371/76776-
dc.description.abstractBackground: Characterization of a rare subgroup of glioblastoma patients who survive for more than 3 years (long-term survival glioblastoma, LTSGBL, patients) may be helpful to identify prognostic factors. Materials and Methods: A molecular-profiling proteomic approach using two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) were used to identify prognostic factors associated with glioblastoma by comparing frozen tumor tissue from LTSGBL patients with matched samples from short-term survival glioblastoma (STSGBL) patients. Western blot (WB) analysis, reverse-transcriptase polymerase chain reaction (RT-PCR) and immmunohistochemical (IHC) staining were used for confirmation. Results: Among most candidate spots identified by 2-DE, lack of overexpression of manganese superoxide dismutase (MnSOD) in LTSGBL samples was consistently observed using WB and RT-PCR. Conclusion: These results suggest that MnSOD expression level in tumor tissue is a candidate marker for the prognosis of glioblastoma patients. Copyright (C) 2009 S. Karger AG, Baselko_KR
dc.language.isoenko_KR
dc.publisherKARGERko_KR
dc.subjectProteomicsko_KR
dc.subjectLong-term survivalko_KR
dc.subjectManganese superoxide dismutaseko_KR
dc.subjectPrognostic factorko_KR
dc.subjectGlioblastomako_KR
dc.titleTissue Expression of Manganese Superoxide Dismutase Is a Candidate Prognostic Marker for Glioblastomako_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박철기-
dc.contributor.AlternativeAuthor정지혜-
dc.contributor.AlternativeAuthor문민정-
dc.contributor.AlternativeAuthor김영임-
dc.contributor.AlternativeAuthor김진현-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor김채용-
dc.contributor.AlternativeAuthor백선하-
dc.contributor.AlternativeAuthor김동규-
dc.contributor.AlternativeAuthor정희원-
dc.contributor.AlternativeAuthor조병규-
dc.identifier.doi10.1159/000231888-
dc.citation.journaltitleONCOLOGY-
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dc.description.tc4-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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