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Tissue Expression of Manganese Superoxide Dismutase Is a Candidate Prognostic Marker for Glioblastoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Jung, Ji Hye | - |
dc.contributor.author | Moon, Min Jeong | - |
dc.contributor.author | Kim, Young-Yim | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Jung, Hee-Won | - |
dc.contributor.author | Cho, Byung-Kyu | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Kim, Chae-Yong | - |
dc.contributor.author | Kim, Jin Hyun | - |
dc.date.accessioned | 2012-06-04T05:12:27Z | - |
dc.date.available | 2012-06-04T05:12:27Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | ONCOLOGY; Vol.77 03월 04일; 178-181 | ko_KR |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76776 | - |
dc.description.abstract | Background: Characterization of a rare subgroup of glioblastoma patients who survive for more than 3 years (long-term survival glioblastoma, LTSGBL, patients) may be helpful to identify prognostic factors. Materials and Methods: A molecular-profiling proteomic approach using two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) were used to identify prognostic factors associated with glioblastoma by comparing frozen tumor tissue from LTSGBL patients with matched samples from short-term survival glioblastoma (STSGBL) patients. Western blot (WB) analysis, reverse-transcriptase polymerase chain reaction (RT-PCR) and immmunohistochemical (IHC) staining were used for confirmation. Results: Among most candidate spots identified by 2-DE, lack of overexpression of manganese superoxide dismutase (MnSOD) in LTSGBL samples was consistently observed using WB and RT-PCR. Conclusion: These results suggest that MnSOD expression level in tumor tissue is a candidate marker for the prognosis of glioblastoma patients. Copyright (C) 2009 S. Karger AG, Basel | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KARGER | ko_KR |
dc.subject | Proteomics | ko_KR |
dc.subject | Long-term survival | ko_KR |
dc.subject | Manganese superoxide dismutase | ko_KR |
dc.subject | Prognostic factor | ko_KR |
dc.subject | Glioblastoma | ko_KR |
dc.title | Tissue Expression of Manganese Superoxide Dismutase Is a Candidate Prognostic Marker for Glioblastoma | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 정지혜 | - |
dc.contributor.AlternativeAuthor | 문민정 | - |
dc.contributor.AlternativeAuthor | 김영임 | - |
dc.contributor.AlternativeAuthor | 김진현 | - |
dc.contributor.AlternativeAuthor | 박성혜 | - |
dc.contributor.AlternativeAuthor | 김채용 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 정희원 | - |
dc.contributor.AlternativeAuthor | 조병규 | - |
dc.identifier.doi | 10.1159/000231888 | - |
dc.citation.journaltitle | ONCOLOGY | - |
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dc.description.tc | 4 | - |
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