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Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment

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dc.contributor.authorKim, Mi-Kyung-
dc.contributor.authorKim, Hee Seung-
dc.contributor.authorOh, Jung-Min-
dc.contributor.authorKim, Su-Hyeong-
dc.contributor.authorJuhnn, Yong-Sung-
dc.contributor.authorSong, Yong-Sang-
dc.contributor.authorLim, Jeong Mook-
dc.contributor.authorHan, Jae Yong-
dc.date.accessioned2012-06-04T05:20:56Z-
dc.date.available2012-06-04T05:20:56Z-
dc.date.issued2010-12-15-
dc.identifier.citationBIOCHEMICAL PHARMACOLOGY; Vol.80 12; 1930-1935ko_KR
dc.identifier.issn0006-2952-
dc.identifier.urihttps://hdl.handle.net/10371/76778-
dc.description.abstractHuman papillomavirus (HPV) infection is considered to be the necessary cause of cervical cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant transformation of cervical cells, inhibiting the tumor suppressors p53 and Rb. However, the role of E5 oncoprotein has been relatively less defined. HPV 16 E5 is a hydrophobic membrane-bound protein which associates with the Golgi apparatus, endoplasmic reticulum and perinuclear membrane. Accumulating evidences have suggested that E5 oncoprotein may also contribute to cervical carcinogenesis through modulating cellular signaling pathways in addition to augmenting the immortalization potential of E6 and E7. Multiple mechanisms, including activation of EGFR or inflammatory cell signaling pathway, have been implicated in malignant transformation by HPV 16 E5. Therefore, targeting E5 may be a rational approach for chemoprevention and treatment of cervical cancer, and understanding its oncogenic processes may help us to design novel therapeutic strategies. In this review, we discussed the roles of HPV 16 E5 in cervical carcinogenesis, altering several cellular signaling pathways involved in cell proliferation, angiogenesis and apoptosis. (C) 2010 Elsevier Inc. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDko_KR
dc.subjectHuman papillomavirusko_KR
dc.subjectCOX-2ko_KR
dc.subjectCervical cancerko_KR
dc.subjectEGFRko_KR
dc.subjectE5ko_KR
dc.titleHuman papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatmentko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor임정묵-
dc.contributor.AlternativeAuthor전용성-
dc.contributor.AlternativeAuthor송용상-
dc.contributor.AlternativeAuthor김수형-
dc.contributor.AlternativeAuthor김미경-
dc.contributor.AlternativeAuthor한재용-
dc.contributor.AlternativeAuthor오정민-
dc.contributor.AlternativeAuthor김희승-
dc.identifier.doi10.1016/j.bcp.2010.07.013-
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