S-Space College of Medicine/School of Medicine (의과대학/대학원) Obstetrics & Gynecology (산부인과전공) Journal Papers (저널논문_산부인과학전공)
Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes
- Oh, Kyung Joon; Lee, Kyung A.; Sohn, Yoo-Kyung; Park, Chan-Wook; Romero, Roberto; Yoon, Bo Hyun; Hong, Joon-Seok
- Issue Date
- AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY; Vol.203 3; -
- chorioamnionitis; preterm birth; ureaplasma; mycoplasmas; interleukin-6; IL-6; intraamniotic inflammation; CRP
- OBJECTIVE: The objective of the study was to compare the intensity of inflammatory responses between intraamniotic infection with genital mycoplasmas and intraamniotic infection with other microorganisms. STUDY DESIGN: We examined the intensity of intraamniotic and maternal inflammatory responses in 99 patients with preterm premature rupture of membranes and a positive amniotic fluid (AF) culture. AF was obtained by transabdominal amniocentesis or at the time of cesarean delivery. Patients were divided according to the recovered microorganisms: (1) genital mycoplasmas (n = 62); (2) other microorganisms (n = 31); or (3) mixed infection (n = 6). RESULTS: The median AF white blood cell (WBC) count, maternal blood WBC count, and plasma C-reactive protein concentrations were significantly higher in patients with intraamniotic infection with genital mycoplasmas than in those with intraamniotic infection with other microorganisms (P < .05 for each). CONCLUSION: Intraamniotic and maternal inflammatory responses are more intense in intraamniotic infection with genital mycoplasmas than in intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes.
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