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Evaluation of serum CA-125 levels for preoperative counseling in endometrioid endometrial cancer: A multi-center study
DC Field | Value | Language |
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dc.contributor.author | Kim, Hee Seung | - |
dc.contributor.author | Park, Chan-Yong | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Lee, Jae-Kwan | - |
dc.contributor.author | Kim, Seok-Mo | - |
dc.contributor.author | Kim, Jae Weon | - |
dc.contributor.author | Cho, Chi-Heum | - |
dc.date.accessioned | 2012-06-04T06:37:45Z | - |
dc.date.available | 2012-06-04T06:37:45Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.citation | GYNECOLOGIC ONCOLOGY; Vol.118 3; 283-288 | ko_KR |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76795 | - |
dc.description.abstract | Objective. To evaluate the role of serum CA-125 levels for preoperative counseling in endometrioid endometrial cancer (EEC). Methods. We reviewed 413 patients with EEC from 6 tertiary medical centers between July 1996 and June 2008. All patients were divided into (1) 4 categories of preoperative serum CA-125 levels: <18 U/mL (n=203); 18-35 U/mL (n = 114); 36-70 U/mL (n = 53); >70 U/mL (n = 43) or (2) 3 categories: low-risk (n = 240); intermediate-risk (n = 99); high-risk diseases (n = 74). Results. Receiver operative curves showed the best cut-off values of 16.2-40.8 U/mL for predicting prognostic factors with 53.4-84.2% of sensitivity, 43.9-81.7% of specificity, 48.8-82.1% of positive predictive value (PPV), 48.5-83.8% of negative predictive value (NPV) and 48.6-83.0% of accuracy. Especially, adnexal involvement was predicted with the highest accuracy (83.0%) at >= 40.8 U/mL. The best cut-off values for preoperative selection of intermediate- to high-risk, and high-risk diseases were 17.3 U/mL and 21.9 U/mL (62.4% and 68.9% of sensitivity; 54.6% and 64.3% of specificity; 57.9% and 64.2% of PPV; 59.2% and 67.4% of NPV, 58.5% and 65.8% of accuracy). Furthermore, >70 U/mL of preoperative serum CA-125 levels was a prognostic factor for poor progression-free and overall survivals. Conclusions. Serum CA-125 levels may not be useful for predicting most of prognostic factors, and may not contribute to preoperative selection of patients with intermediate- or high-risk disease who need adjuvant radiotherapy in EEC. However, serum CA-125 levels may be helpful in preoperative counseling for young patients who want ovarian preservation, and >70 U/mL could be considered as a risk factor for poor survival. (C) 2010 Elsevier Inc. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | ko_KR |
dc.subject | Preoperative | ko_KR |
dc.subject | Endometrioid endometrial cancer | ko_KR |
dc.subject | Serum CA-125 levels | ko_KR |
dc.subject | Prognostic factors | ko_KR |
dc.subject | Survival | ko_KR |
dc.title | Evaluation of serum CA-125 levels for preoperative counseling in endometrioid endometrial cancer: A multi-center study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김희승 | - |
dc.contributor.AlternativeAuthor | 박찬용 | - |
dc.contributor.AlternativeAuthor | 이종민 | - |
dc.contributor.AlternativeAuthor | 이재관 | - |
dc.contributor.AlternativeAuthor | 조치흠 | - |
dc.contributor.AlternativeAuthor | 김석모 | - |
dc.contributor.AlternativeAuthor | 김재원 | - |
dc.identifier.doi | 10.1016/j.ygyno.2010.04.018 | - |
dc.citation.journaltitle | GYNECOLOGIC ONCOLOGY | - |
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dc.description.tc | 1 | - |
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