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Estrogen receptor beta gene+1730 G/A polymorphism in women with polycystic ovary syndrome
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin Ju | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Choung, Seon Ha | - |
dc.contributor.author | Yoon, Sang Ho | - |
dc.contributor.author | Moon, Shin Yong | - |
dc.contributor.author | Lee, Gyoung Hoon | - |
dc.date.accessioned | 2012-06-05T00:45:41Z | - |
dc.date.available | 2012-06-05T00:45:41Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | FERTILITY AND STERILITY; Vol.93 6; 1942-1947 | ko_KR |
dc.identifier.issn | 0015-0282 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76819 | - |
dc.description.abstract | Objective: To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS). Design: Case control study. Setting: University Department of Obstetrics and Gynecology. Patient(s): Women with (n = 138) or without (n = 290) PCOS. Intervention(s): Genotyping was performed by polymerase chain reaction restriction fragment-length polymorphism analysis. Main Outcome Measure(s): Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene. Result(s): There was a significant difference in the genotype distribution between the patients with PCOS and controls (non-GO rates were 22.1% for patients with PCOS and 36.6% for controls). There was also a significant difference in the G and A allele frequencies between these two groups (11.7% in patients vs. 19.1% in controls with A allele). But in patients with PCOS there were no significant differences in the serum levels of hormones, biochemical variables, or ovarian morphology between GG and non-GG genotypes. Conclusion(s): The ER-beta gene +1730 G/A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS. (Fertil Steril (R) 2010;93:1942-7. (C)2010 by American Society for Reproductive Medicine.) | ko_KR |
dc.description.sponsorship | Supported by a grant from the Korea Health 21 R&D Project, Ministry of
Health and Welfare, Republic of Korea (01-PJ10-PG6-01GN13-0002). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.subject | Estrogen receptor β | ko_KR |
dc.subject | +1730 G/A polymorphism | ko_KR |
dc.subject | gene | ko_KR |
dc.subject | polycystic ovary syndrome | ko_KR |
dc.title | Estrogen receptor beta gene+1730 G/A polymorphism in women with polycystic ovary syndrome | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김진주 | - |
dc.contributor.AlternativeAuthor | 최영민 | - |
dc.contributor.AlternativeAuthor | 정선하 | - |
dc.contributor.AlternativeAuthor | 윤상호 | - |
dc.contributor.AlternativeAuthor | 이경훈 | - |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.identifier.doi | 10.1016/j.fertnstert.2008.12.040 | - |
dc.citation.journaltitle | FERTILITY AND STERILITY | - |
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dc.description.tc | 5 | - |
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