Publications
Detailed Information
Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Mi Jeong | - |
dc.contributor.author | Kim, Sung-Su | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Jung, Hun Soon | - |
dc.contributor.author | Kim, Su-Hyeong | - |
dc.contributor.author | Marquez, Victor E. | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Nephew, Kenneth P. | - |
dc.contributor.author | Song, Yong-Sang | - |
dc.contributor.author | Balch, Curt | - |
dc.date.accessioned | 2012-06-05T01:24:44Z | - |
dc.date.available | 2012-06-05T01:24:44Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | CARCINOGENESIS; Vol.31 6; 974-983 | ko_KR |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76828 | - |
dc.description.abstract | Unlike epigenetic silencing of tumor suppressor genes, the role of epigenetic derepression of cancer-promoting genes or oncogenes in carcinogenesis remains less well understood. The tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer and their overexpression was previously reported to promote the migration and invasion of ovarian epithelial cells. Here, we show that the expression of claudin-3 and claudin-4 is repressed in ovarian epithelial cells in association with promoter `bivalent` histone modifications, containing both the activating trimethylated histone H3 lysine 4 (H3K4me3) mark and the repressive mark of trimethylated histone H3 lysine 27 (H3K27me3). During ovarian tumorigenesis, derepression of CLDN3 and CLDN4 expression correlates with loss of H3K27me3 in addition to trimethylated histone H4 lysine 20 (H4K20me3), another repressive histone modification. Although CLDN4 repression was accompanied by both DNA hypermethylation and repressive histone modifications, DNA methylation was not required for CLDN3 repression in immortalized ovarian epithelial cells. Moreover, activation of both CLDN3 and CLDN4 in ovarian cancer cells was associated with simultaneous changes in multiple histone modifications, whereas H3K27me3 loss alone was insufficient for their derepression. CLDN4 repression was robustly reversed by combined treatment targeting both DNA demethylation and histone acetylation. Our study strongly suggests that in addition to the well-known chromatin-associated silencing of tumor suppressor genes, epigenetic derepression by the conversely related loss of repressive chromatin modifications also contributes to ovarian tumorigenesis via activation of cancer-promoting genes or candidate oncogenes. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | OXFORD UNIV PRESS | ko_KR |
dc.title | Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 권미정 | - |
dc.contributor.AlternativeAuthor | 김성수 | - |
dc.contributor.AlternativeAuthor | 최윤라 | - |
dc.contributor.AlternativeAuthor | 정훈순 | - |
dc.contributor.AlternativeAuthor | 김수형 | - |
dc.contributor.AlternativeAuthor | 송용상 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.identifier.doi | 10.1093/carcin/bgp336 | - |
dc.citation.journaltitle | CARCINOGENESIS | - |
dc.description.citedreference | Balch C, 2009, ENDOCRINOLOGY, V150, P4003, DOI 10.1210/en.2009-0404 | - |
dc.description.citedreference | Kwon MJ, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006162 | - |
dc.description.citedreference | Yuan XQ, 2009, MOL CANCER THER, V8, P1906, DOI 10.1158/1535-7163.MCT-09-0106 | - |
dc.description.citedreference | Huang YH, 2009, P NATL ACAD SCI USA, V106, P3426, DOI 10.1073/pnas.0813348106 | - |
dc.description.citedreference | Cui KR, 2009, CELL STEM CELL, V4, P80, DOI 10.1016/j.stem.2008.11.011 | - |
dc.description.citedreference | Golebiewska A, 2009, STEM CELLS, V27, P1298, DOI 10.1002/stem.59 | - |
dc.description.citedreference | Simon JA, 2008, MUTAT RES-FUND MOL M, V647, P21, DOI 10.1016/j.mrfmmm.2008.07.010 | - |
dc.description.citedreference | Vaissiere T, 2008, MUTAT RES-REV MUTAT, V659, P40, DOI 10.1016/j.mrrev.2008.02.004 | - |
dc.description.citedreference | Fujii S, 2008, J BIOL CHEM, V283, P17324, DOI 10.1074/jbc.M800224200 | - |
dc.description.citedreference | Lan F, 2008, CURR OPIN CELL BIOL, V20, P316, DOI 10.1016/j.ceb.2008.03.004 | - |
dc.description.citedreference | Kondo Y, 2008, NAT GENET, V40, P741, DOI 10.1038/ng.159 | - |
dc.description.citedreference | Jiang X, 2008, CANCER CELL, V13, P529, DOI 10.1016/j.ccr.2008.04.019 | - |
dc.description.citedreference | Esteller M, 2008, NEW ENGL J MED, V358, P1148 | - |
dc.description.citedreference | Honda H, 2007, CANCER BIOL THER, V6, P1733 | - |
dc.description.citedreference | Choi YL, 2007, HISTOL HISTOPATHOL, V22, P1185 | - |
dc.description.citedreference | Agger K, 2007, NATURE, V449, P731, DOI 10.1038/nature06145 | - |
dc.description.citedreference | Lee ER, 2007, STEM CELLS, V25, P2191, DOI 10.1634/stemcells.2007-0203 | - |
dc.description.citedreference | McGarvey KM, 2007, CANCER RES, V67, P5097, DOI 10.1158/0008-5472.CAN-06-2029 | - |
dc.description.citedreference | Berger SL, 2007, NATURE, V447, P407, DOI 10.1038/nature05915 | - |
dc.description.citedreference | Tan J, 2007, GENE DEV, V21, P1050, DOI 10.1101/gad.1524107 | - |
dc.description.citedreference | Esteller M, 2007, NAT REV GENET, V8, P286, DOI 10.1038/nrg2005 | - |
dc.description.citedreference | Litkouhi B, 2007, NEOPLASIA, V9, P304, DOI 10.1593/neo.07118 | - |
dc.description.citedreference | Issaeva I, 2007, MOL CELL BIOL, V27, P1889, DOI 10.1128/MCB.01506-06 | - |
dc.description.citedreference | Kouzarides T, 2007, CELL, V128, P693, DOI 10.1016/j.cell.2007.02.005 | - |
dc.description.citedreference | Schlesinger Y, 2007, NAT GENET, V39, P232, DOI 10.1038/ng1950 | - |
dc.description.citedreference | Ohm JE, 2007, NAT GENET, V39, P237, DOI 10.1038/ng1972 | - |
dc.description.citedreference | Sparmann A, 2006, NAT REV CANCER, V6, P846, DOI 10.1038/nrcd1991 | - |
dc.description.citedreference | Honda H, 2006, J BIOL CHEM, V281, P21433, DOI 10.1074/jbc.M603767200 | - |
dc.description.citedreference | Abbosh PH, 2006, CANCER RES, V66, P5582, DOI 10.1158/0008-5472.CAN-05-3575 | - |
dc.description.citedreference | Frigola J, 2006, NAT GENET, V38, P540, DOI 10.1038/ng1781 | - |
dc.description.citedreference | Bernstein BE, 2006, CELL, V125, P315, DOI 10.1016/j.cell.2006.02.041 | - |
dc.description.citedreference | Coral S, 2006, J CELL PHYSIOL, V207, P58, DOI 10.1002/jcp.20540 | - |
dc.description.citedreference | Vire E, 2006, NATURE, V439, P871, DOI 10.1038/nature04431 | - |
dc.description.citedreference | Baylin SB, 2006, NAT REV CANCER, V6, P107, DOI 10.1038/nrc1799 | - |
dc.description.citedreference | Guo ZS, 2006, CANCER RES, V66, P1105, DOI 10.1158/0008-5472.CAN-05-3020 | - |
dc.description.citedreference | Shepherd TG, 2006, NAT PROTOC, V1, P2643, DOI 10.1038/nprot.2006.328 | - |
dc.description.citedreference | Morin PJ, 2005, CANCER RES, V65, P9603, DOI 10.1158/0008-5472.CAN-05-2782 | - |
dc.description.citedreference | Cha TL, 2005, SCIENCE, V310, P306, DOI 10.1126/science.1118947 | - |
dc.description.citedreference | Fuks F, 2005, CURR OPIN GENET DEV, V15, P490, DOI 10.1016/j.gde.2005.08.002 | - |
dc.description.citedreference | Agarwal R, 2005, CANCER RES, V65, P7378, DOI 10.1158/0008-5472.CAN-05-1036 | - |
dc.description.citedreference | Sakatani T, 2005, SCIENCE, V307, P1976, DOI 10.1126/science.1108080 | - |
dc.description.citedreference | Turner BM, 2005, NAT STRUCT MOL BIOL, V12, P110, DOI 10.1038/nsmb0205-110 | - |
dc.description.citedreference | Sarg B, 2004, J BIOL CHEM, V279, P53458, DOI 10.1074/jbc.M409099200 | - |
dc.description.citedreference | Kourmouli N, 2004, J CELL SCI, V117, P2491, DOI 10.1242/jcs.01238 | - |
dc.description.citedreference | Wang Y, 2004, BIOINFORMATICS, V20, P1170, DOI 10.1093/bioinformatics/bth059 | - |
dc.description.citedreference | Sundfeldt K, 2003, MOL CELL ENDOCRINOL, V202, P89, DOI 10.1016/S0303-7207(03)00068-6 | - |
dc.description.citedreference | Gaudet F, 2003, SCIENCE, V300, P489 | - |
dc.description.citedreference | Fischle W, 2003, CURR OPIN CELL BIOL, V15, P172, DOI 10.1016/S0955-0674(03)00013-9 | - |
dc.description.citedreference | Turner BM, 2002, CELL, V111, P285 | - |
dc.description.citedreference | Hanahan D, 2000, CELL, V100, P57 | - |
dc.description.citedreference | Dyck HG, 1996, INT J CANCER, V69, P429 | - |
dc.description.tc | 12 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.