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Estrogen receptor alpha gene polymorphisms in patients with idiopathic premature ovarian failure
DC Field | Value | Language |
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dc.contributor.author | Yoon, Sang Ho | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Hong, Min A. | - |
dc.contributor.author | Lee, Gyoung Hoon | - |
dc.contributor.author | Im, Hyoung June | - |
dc.contributor.author | Kang, Byung Moon | - |
dc.contributor.author | Moon, Shin Yong | - |
dc.contributor.author | Yoon, Byung Koo | - |
dc.contributor.author | Min, Eung Gi | - |
dc.contributor.author | Kim, Jin Ju | - |
dc.date.accessioned | 2012-06-05T02:20:44Z | - |
dc.date.available | 2012-06-05T02:20:44Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | HUMAN REPRODUCTION; Vol.25 1; 283-287 | ko_KR |
dc.identifier.issn | 0268-1161 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76835 | - |
dc.description.abstract | It has been reported that polymorphisms in the estrogen receptor (ER)-alpha gene (ESR1) may be associated with reproductive patterns of women. This study was performed to investigate whether the genetic polymorphisms of the ER-alpha gene are associated with idiopathic premature ovarian failure (POF) in a Korean population. The subjects were 126 idiopathic POF patients and 221 post-menopausal controls recruited from university hospitals between 1999 and 2004. Genotyping was performed by MGB primer/probe Taqman assay. Haplotypes were deduced by using the Haploview version 4.1. Bonferroni correction was applied for the correction of multiple testing. There was no significant difference in the allele distribution of the ER-alpha gene (TA)n repeats between the POF and the control group. For the PvuII polymorphism, the POF group showed a higher frequency of TT genotype compared with the controls (41.3 versus 26.3%, P = 0.004, 98.75% CI 1.8-28.2%). No significant difference was found in the distribution of the XbaI polymorphism between the POF and the control group. Haplotype analysis showed that the frequency of TA haplotype was significantly higher in the POF patients compared with the controls (64.7 versus 52.7%, P = 0.002, 98.75% CI 2.4-21.6%). These findings suggest that the ER-alpha gene polymorphisms may be associated with idiopathic POF. | ko_KR |
dc.description.sponsorship | This study was supported by a grant (01-PJ10-PG6-01GN13-0002)
from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | OXFORD UNIV PRESS | ko_KR |
dc.subject | estrogen receptor alpha | ko_KR |
dc.subject | premature ovarian failure | ko_KR |
dc.subject | polymorphism | ko_KR |
dc.title | Estrogen receptor alpha gene polymorphisms in patients with idiopathic premature ovarian failure | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 윤상호 | - |
dc.contributor.AlternativeAuthor | 최영민 | - |
dc.contributor.AlternativeAuthor | 홍민아 | - |
dc.contributor.AlternativeAuthor | 이경훈 | - |
dc.contributor.AlternativeAuthor | 김진주 | - |
dc.contributor.AlternativeAuthor | 임형준 | - |
dc.contributor.AlternativeAuthor | 민응기 | - |
dc.contributor.AlternativeAuthor | 강병문 | - |
dc.contributor.AlternativeAuthor | 윤병구 | - |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.identifier.doi | 10.1093/humrep/dep375 | - |
dc.citation.journaltitle | HUMAN REPRODUCTION | - |
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dc.description.tc | 3 | - |
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