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Exposures to Particulate Matter and Polycyclic Aromatic Hydrocarbons and Oxidative Stress in Schoolchildren

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dc.contributor.authorBae, Sanghyuk-
dc.contributor.authorPan, Xiao-Chuan-
dc.contributor.authorKim, Su-Young-
dc.contributor.authorPark, Kwangsik-
dc.contributor.authorKim, Ho-
dc.contributor.authorHong, Yun-Chul-
dc.contributor.authorKim, Yoon-Hee-
dc.date.accessioned2012-06-07T08:28:48Z-
dc.date.available2012-06-07T08:28:48Z-
dc.date.issued2010-04-
dc.identifier.citationENVIRONMENTAL HEALTH PERSPECTIVES; Vol.118 4; 579-583ko_KR
dc.identifier.issn0091-6765-
dc.identifier.urihttps://hdl.handle.net/10371/76883-
dc.description.abstractBACKGROUND: Air pollution is known to contribute to respiratory and cardiovascular mortality, and morbidity. Oxidative stress has been suggested as one of the main mechanisms for these effects on health. OBJECTIVE: The aim of this study was to analyze the effects of exposure to particulate matter (PM) with aerodynamic diameters <= 10 mu m (PM(10)) and <= 2.5 mu M (PM(2.5)) and polycyclic aromatic hydrocarbons (PAHs) on urinary malondialdehyde (MDA) levels in schoolchildren. METHODS: The study population consisted of 120 schoolchildren. The survey and measurements were conducted in four cities two in China (Ala Shan and Beijing) and two in Korea (Jeju and Seoul) between 4 and 9 June 2007. We measured daily ambient levels of PM and their metal components at the selected schools during the study period. We also measured urinary 1-hydroxypyrene (1-OHP) and 2-naphthol, to assess PAH exposure, and MDA, to assess oxidative stress. Measurements were conducted once a day for 5 consecutive days. We constructed a linear mixed model after adjusting for individual variables to estimate the effects of PM and PAH on oxidative stress. RESULTS: We found statistically significant increases in urinary MDA levels with ambient PM concentrations from the current day to the 2 previous days (p < 0.0001). Urinary 1-OHP level also showed a positive association with urinary MDA level, which was statistically significant with or without PM in the model (p < 0.05). Outdoor PM and urinary 1-OHP were synergistically associated with urinary MDA levels. Some metals bound to PM(10) (aluminum, iron, strontium, magnesium, silicon, arsenic, barium, zinc, copper, and cadmium) and PM(2.5) (magnesium, iron, strontium, arsenic, cadmium, zinc, aluminum, mercury, barium, and copper) also had significant associations with urinary MDA level. CONCLUSION: Exposure to PM air pollution and PAHs was associated with oxidative stress in schoolchildren.ko_KR
dc.language.isoenko_KR
dc.publisherUS DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCEko_KR
dc.subjectchildrenko_KR
dc.subjectparticulate matterko_KR
dc.subjectoxidative stressko_KR
dc.subjectPAHko_KR
dc.subjectpanel studyko_KR
dc.subjectmetalko_KR
dc.titleExposures to Particulate Matter and Polycyclic Aromatic Hydrocarbons and Oxidative Stress in Schoolchildrenko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor배상혁-
dc.contributor.AlternativeAuthor김수영-
dc.contributor.AlternativeAuthor박광식-
dc.contributor.AlternativeAuthor김윤희-
dc.contributor.AlternativeAuthor김호-
dc.contributor.AlternativeAuthor홍윤철-
dc.identifier.doi10.1289/ehp.0901077-
dc.citation.journaltitleENVIRONMENTAL HEALTH PERSPECTIVES-
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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