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Polymorphisms in innate immunity genes and risk of childhood leukemia
DC Field | Value | Language |
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dc.contributor.author | Han, Sohee | - |
dc.contributor.author | Lan, Qing | - |
dc.contributor.author | Park, Ae Kyung | - |
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Seo, Jong Jin | - |
dc.contributor.author | Ahn, Yoon-Ok | - |
dc.contributor.author | Kim, Ho | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Choi, Ji Eun | - |
dc.contributor.author | Koo, Hong Hoe | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Park, Sue K. | - |
dc.date.accessioned | 2012-06-08T00:55:24Z | - |
dc.date.available | 2012-06-08T00:55:24Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | HUMAN IMMUNOLOGY; Vol.71 7; 727-730 | ko_KR |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76899 | - |
dc.description.abstract | Objectives—To evaluate whether candidate genes in innate immunity are associated with
childhood leukemia, we conducted an association study with the 1,536 SNPs in 203 genes related to innate immunity. Methods—Incident childhood leukemia cases (n=136) aged from 0 to 18 were recruited from three teaching hospitals in Seoul between 2003 and 2006. Non-cancer controls (n=140) were frequencymatched to cases by age and gender. The information on the characteristics of children and their parents were collected by trained interviewers using structured questionnaire. Candidate genes were selected based on SNP databases (CGAP and SNP500 database), and genotype assay was performed using GoldenGate (Illumina) oligonucleotide pool assay (OPA). False discovery rate (FDR), permutation test, and haplotype analyses were used to identify the SNP with significant association with childhood leukemia. Childhood leukemia risk was estimated as ORs and 95% CIs adjusted for age, gender and birth weight. Results—Fourteen SNPs in 13 genes (LMAN1, TLR4, STAT4, CCR9, MBP, ZP1, C8B, XDH, C7, C1QG, FGF2, LOC390183, and STAT6) were significantly associated with childhood leukemia risk (FDR p-values <0.05). In particular, LMAN1 rs1127220, TLR4 rs11536897, STAT4 rs13020076, CCR9 rs1471962, and MBP rs10514234 were significant in 5,000 permutation tests (Permutation p-value <0.05). The most significant association with childhood leukemia risk was for the LMAN1 rs1127220 that is in the protein-coding region, this finding was also supported by haplotype analysis. Conclusions—A number of innate immunity related genes are associated with childhood leukemia, suggesting possible links between the innate immunity system and development of the childhood leukemia. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.subject | Childhood leukemia | ko_KR |
dc.subject | Innate immunity | ko_KR |
dc.subject | Single-nucleotide polymorphism | ko_KR |
dc.title | Polymorphisms in innate immunity genes and risk of childhood leukemia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 한소희 | - |
dc.contributor.AlternativeAuthor | 박애경 | - |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 박수경 | - |
dc.contributor.AlternativeAuthor | 안효섭 | - |
dc.contributor.AlternativeAuthor | 신희영 | - |
dc.contributor.AlternativeAuthor | 강형진 | - |
dc.contributor.AlternativeAuthor | 구홍회 | - |
dc.contributor.AlternativeAuthor | 서종진 | - |
dc.contributor.AlternativeAuthor | 최지은 | - |
dc.contributor.AlternativeAuthor | 안윤옥 | - |
dc.contributor.AlternativeAuthor | 김호 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1016/j.humimm.2010.04.004 | - |
dc.citation.journaltitle | HUMAN IMMUNOLOGY | - |
dc.description.citedreference | Brink TC, 2009, BIOGERONTOLOGY, V10, P721, DOI 10.1007/s10522-009-9219-1 | - |
dc.description.citedreference | Lee JY, 2009, CARCINOGENESIS, V30, P1528, DOI 10.1093/carcin/bgp084 | - |
dc.description.citedreference | Angeletti S, 2009, HUM IMMUNOL, V70, P729, DOI 10.1016/j.humimm.2009.04.026 | - |
dc.description.citedreference | Shen M, 2009, ENVIRON MOL MUTAGEN, V50, P285, DOI 10.1002/em.20452 | - |
dc.description.citedreference | Rajaraman P, 2009, CANCER EPIDEM BIOMAR, V18, P1651, DOI 10.1158/1055-9965.EPI-08-1041 | - |
dc.description.citedreference | Lee KM, 2009, LEUKEMIA RES, V33, P250, DOI 10.1016/j.leukres.2008.06.031 | - |
dc.description.citedreference | MOCKELMANN N, 2009, BMC GASTROENTEROL, V20, P79 | - |
dc.description.citedreference | Federico A, 2007, INT J CANCER, V121, P2381, DOI 10.1002/ijc.23192 | - |
dc.description.citedreference | Zamar D, 2007, J STAT SOFTW, V21, P1 | - |
dc.description.citedreference | Mayor NP, 2007, J CLIN ONCOL, V25, P4262, DOI 10.1200/JCO.2007.12.1897 | - |
dc.description.citedreference | Roman E, 2007, AM J EPIDEMIOL, V165, P496, DOI 10.1093/aje/kwk039 | - |
dc.description.citedreference | Tower RL, 2007, CRIT REV CL LAB SCI, V44, P203, DOI 10.1080/10408360601147536 | - |
dc.description.citedreference | Fraser DA, 2006, J LEUKOCYTE BIOL, V80, P107, DOI 10.1189/jlb.1105683 | - |
dc.description.citedreference | Bruns HA, 2006, CRIT REV ONCOL HEMAT, V57, P245, DOI 10.1016/j.critrevonc.2005.08.005 | - |
dc.description.citedreference | Elmaagacli AH, 2006, TRANSPLANTATION, V81, P247, DOI 10.1097/01.tp.0000188671.94646.16 | - |
dc.description.citedreference | Wu SL, 2005, CANCER, V103, P1054, DOI 10.1002/cncr.20869 | - |
dc.description.citedreference | Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457 | - |
dc.description.citedreference | Silva CM, 2004, ONCOGENE, V23, P8017, DOI 10.1038/sj.onc.1208159 | - |
dc.description.citedreference | PACKER BR, 2004, NUCLEIC ACIDS RES, V32, P528 | - |
dc.description.citedreference | Schmiegelow K, 2002, BLOOD, V100, P3757, DOI 10.1182/blood-2002-06-1627 | - |
dc.description.citedreference | Kinlen L, 2002, BRIT J CANCER, V86, P732, DOI 10.1038/sj/bjc/6600113 | - |
dc.description.citedreference | Lentsch AB, 2001, J CLIN INVEST, V108, P1475 | - |
dc.description.citedreference | Balkwill F, 2001, LANCET, V357, P539 | - |
dc.description.citedreference | KINLEN LJ, 2001, BRIT J CANCER, V84 | - |
dc.description.citedreference | Takeda K, 2000, CYTOKINE GROWTH F R, V11, P199 | - |
dc.description.citedreference | Everett H, 1999, TRENDS MICROBIOL, V7, P160 | - |
dc.description.citedreference | Kinlen LJ, 1997, BRIT J CANCER, V76, P1539 | - |
dc.description.citedreference | Alexander FE, 1997, BRIT J CANCER, V75, P457 | - |
dc.description.citedreference | Lu ML, 1996, P NATL ACAD SCI USA, V93, P8977 | - |
dc.description.citedreference | ROMAN E, 1991, ARCH DIS CHILD, V66, P179 | - |
dc.description.citedreference | KINLEN L, 1988, LANCET, V2, P1323 | - |
dc.description.citedreference | GREAVES MF, 1988, LEUKEMIA, V2, P120 | - |
dc.description.tc | 2 | - |
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