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Folate intake and the risk of colorectal cancer in a Korean population

Cited 25 time in Web of Science Cited 29 time in Scopus
Authors
Kim, J.; Kim, D. H.; Lee, B. H.; Kang, S. H.; Lim, S. Y.; Ahn, Y. O.; Suh, Y. K.; Lee, H. J.
Issue Date
2009-08
Publisher
NATURE PUBLISHING GROUP
Citation
EUROPEAN JOURNAL OF CLINICAL NUTRITION; Vol.63 9; 1057-1064
Keywords
colorectal cancerrectumfolatecolondiet
Abstract
Background: Folate, a water-soluble B vitamin and one of the major micronutrients in vegetables, is known as an essential factor for the de novo biosynthesis of purines and thymidylate, and it plays an important role in DNA synthesis and replication. Thus, folate deficiency results in ineffective DNA synthesis, and has been shown to induce the initiation and progression of colorectal cancer (CRC). Recently, the incidence of CRC in Korea has increased markedly in both men and women; this trend may be related to the adoption of a more `westernized` lifestyle, including dietary habits. Objective: A hospital-based case-control study was conducted to examine the relationship between folate intake and the risk of CRC within a Korean population. Methods: A total of 596 cases and 509 controls, aged 30-79 years, were recruited from two university hospitals. Site-and sex-specific odds ratios (ORs) were estimated using logistic regression models. Results: Cases were more frequently found to have a family history of CRC among first-degree relatives, to consume more alcohol, to be more likely current smokers and less likely to participate in vigorous physical activity than the controls. In the overall data for men and women combined, multivariate ORs (95% confidence interval (CI), P for trend) comparing the highest vs the lowest quartile of dietary folate intake were: 0.47 (0.32-0.69, <0.001) for CRC, 0.42 (0.26-0.69, <0.001) for colon cancer and 0.48 (0.28-0.81, 0.007) for rectal cancer. An inverse association was also found in women with dietary folate intake: 0.36 (0.20-0.64, <0.001) for CRC, 0.34 (0.16-0.70, 0.001) for colon cancer and 0.30 (0.12-0.74, 0.026) for rectal cancer, but not in men. In addition, the total folate intake of women was strongly associated with a reduced risk of rectal cancer (OR, 0.38; 95% CI, 0.17-0.88; P for trend = 0.04). Conclusion: We found a statistically significant relationship between higher dietary folate intake and reduced risk of CRC, colon cancer and rectal cancer in women. A significant association is indicated between higher total folate intake and reduced risk of rectal cancer in women. European Journal of Clinical Nutrition (2009) 63, 1057-1064; doi:10.1038/ejcn.2009.37; published online 24 June 2009
ISSN
0954-3007
Language
English
URI
https://hdl.handle.net/10371/76917
DOI
https://doi.org/10.1038/ejcn.2009.37
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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