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Epstein-Barr virus antibody level and gastric cancer risk in Korea: a nested case-control study

Cited 12 time in Web of Science Cited 16 time in Scopus
Authors
Kim, Y.; Shin, A.; Gwack, J.; Ko, K-P; Park, S. K.; Kang, D.; Yoo, K-Y; Hong, Y-C; Kim, C-S
Issue Date
2009-07
Publisher
NATURE PUBLISHING GROUP
Citation
BRITISH JOURNAL OF CANCER; Vol.101 3; 526-529
Keywords
stomach neoplasmsEpstein-Barr virusKoreanested case-control study
Abstract
BACKGROUND: Few cohort studies have investigated Epstein-Barr virus (EBV) infection before the occurrence of gastric cancer. METHODS: Among 14 440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein-Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs). RESULTS: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95% confidence interval (CI): 0.62-3.06) or EBNA IgG (OR: 0.87, 95% CI: 0.51-1.46) were not associated with gastric cancer risk. CONCLUSION: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.
ISSN
0007-0920
Language
English
URI
https://hdl.handle.net/10371/76927
DOI
https://doi.org/10.1038/sj.bjc.6605146
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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