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Soybean Product Intake Modifies the Association between Interleukin-10 Genetic Polymorphisms and Gastric Cancer Risk

Cited 38 time in Web of Science Cited 44 time in Scopus
Authors
Ko, Kwang-Pil; Park, Sue K.; Cho, Lisa Y.; Gwack, Jin; Shin, Aesun; Kim, Yeonju; Chang, Soung-Hoon; Yoo, Keun-Young; Shin, Hai-Rim; Kang, Daehee; Kim, Cheong Sik; Yang, Jae Jeong
Issue Date
2009-05
Publisher
AMER SOC NUTRITIONAL SCIENCE
Citation
JOURNAL OF NUTRITION; Vol.139 5; 1008-1012
Abstract
In this study, our aim was to investigate the association of inflammation-related genetic polymorphisms and gastric cancer risk and to examine whether the combined effect of soybean product intake modified cancer risk. Eighty-four incident gastric cancer cases and 336 matched controls were selected from the Korean Multi-Center Cancer Cohort. We selected 14 single nucleotide polymorphisms (SNP) from 5 genes [interleukin (IL)-1 beta, IL-2, IL-4, IL-B, and IL-10] and used unconditional logistic regression model to calculate the odds ratios (OR) and 95% Cl adjusting for H. pylori seropositivity, smoking, age, sex, enrollment year, and residential area. The risk for gastric cancer in relation to genetic polymorphisms and haplotypes were assessed according to soybean product intake levels. Although no single SNP effect was found, the combined effect between IL-10 gene variants of -592 GG/GA, -819 TC/CC, or - 1082 AG/GG and low intake of soybean products had an increased risk for gastric cancer compared with the group with no risk gene variants and a high intake of soybean products (OR [95% Cl] = 2.82 [1.04-7.62], 2.75 [1.02-7.44], and 4.34 [1.51-12.5], respectively). Among the low-soybean product intake group, IL-10 CCG haplotype had an increased risk of gastric cancer (OR = 3.38 [1.40-8.13]) relative to the ATA haplotype. Our results suggest that the association between IL-10 genetic polymorphisms and gastric cancer risk was modified by soybean product intake. J. Nutr. 139: 1008-1012, 2009.
ISSN
0022-3166
Language
English
URI
http://hdl.handle.net/10371/76929
DOI
https://doi.org/10.3945/jn.108.101865
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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