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Mesenchymal Stem-Cell Transplantation for Hypoxic-Ischemic Brain Injury in Neonatal Rat Model

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dc.contributor.authorLee, Jin A.-
dc.contributor.authorKim, Beyong Il-
dc.contributor.authorJo, Chris Hyunchul-
dc.contributor.authorChoi, Chang Won-
dc.contributor.authorKim, Han-Suk-
dc.contributor.authorChoi, Jung-Hwan-
dc.contributor.authorYoon, Kang-Sup-
dc.contributor.authorKim, Ee-Kyung-
dc.date.accessioned2012-06-12T02:30:57Z-
dc.date.available2012-06-12T02:30:57Z-
dc.date.issued2010-01-
dc.identifier.citationPEDIATRIC RESEARCH; Vol.67 1; 42-46ko_KR
dc.identifier.issn0031-3998-
dc.identifier.urihttp://hdl.handle.net/10371/76982-
dc.description.abstractNeonatal hypoxic-ischemic brain injury (HIE) remains a major cause of neurologic disabilities. However, many experimental therapies have shown limited successes. We assessed whether human mesenchymal stem cells (MSCs) could be transplanted in the HIE rat brain to improve neurologic disabilities. P7 SD rats were either subjected to left carotid artery ligation and hypoxic exposure [hypoxia-ischemia (HI)) or sham operation and normoxic exposure (sham). On P10, rat pubs received either PKH26-labeled MSCs or buffer via intracardial injection, resulting in four experimental groups: sham-buffer, sham-MSC, HI-buffer. and HI-MSC. Cylinder test and accelerating rotarod test were performed 14, 20 307 and 40 d after injection. Six weeks after injection, cresyl violet and double immunofluorescence staining were performed. MSCs were transplanted to the whole brain mainly after HI. Glial fibrillary acidic protein and OX42 were more abundantly colocalized with MSC than neuronal specific nuclear protein or myelin basic protein. There were no significant differences in the total amounts and cell types between the lesioned and nonlesioned hemisphere. The lesioned hemispheric volume was decreased after HI (p = 0.012) but not restored by MSC. Neurologic performance was significantly impaired only on the cylinder test after HI (p = 0.034), and MSC transplants improved it (p = 0.010). These suggest MSC can be a candidate for the treatment of neonatal HIE. (Pediatr Res 67: 42-46, 2010)ko_KR
dc.language.isoenko_KR
dc.publisherINT PEDIATRIC RESEARCH FOUNDATION, INCko_KR
dc.titleMesenchymal Stem-Cell Transplantation for Hypoxic-Ischemic Brain Injury in Neonatal Rat Modelko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이진아-
dc.contributor.AlternativeAuthor김병일-
dc.contributor.AlternativeAuthor조현철-
dc.contributor.AlternativeAuthor최창원-
dc.contributor.AlternativeAuthor김이경-
dc.contributor.AlternativeAuthor김한석-
dc.contributor.AlternativeAuthor윤강섭-
dc.contributor.AlternativeAuthor최중환-
dc.citation.journaltitlePEDIATRIC RESEARCH-
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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