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Immunogenicity of Haemophilus influenzae Type b Conjugate Vaccines in Korean Infants: A Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyunju | - |
dc.contributor.author | Hahn, Seokyung | - |
dc.contributor.author | Lee, Hoan Jong | - |
dc.contributor.author | Kim, Kyung-Hyo | - |
dc.date.accessioned | 2012-06-12T02:35:57Z | - |
dc.date.available | 2012-06-12T02:35:57Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 1; 90-96 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76983 | - |
dc.description.abstract | A meta-analysis was performed on the immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines after 2 (2 and 4 months) and 3 doses (2, 4, and 6 months) in Korean infants. A database search of MEDLINE, KoreaMed, and Korean Medical Database was done. The primary outcome measure was the proportion of infants with anti-polyribosylribitol phosphate (PRP) concentrations >= 1.0 mu g/mL. Eight studies including eleven trials were retrieved. One trial reported on the diphtheria toxoid conjugate vaccine (PRP-D) and 2 trials each on the mutant diphtheria toxin (PRP-CRM) and Neisseria meningitidis outer-membrane protein (PRP-OMP) conjugate vaccine. Heterogeneity in study designs between trials on PRP-CRM was noted and one trial reported on a monovalent and another on a combination PRP-OMP vaccine. Thus, a meta-analysis was conducted only on the tetanus toxoid conjugate vaccine (PRP-T). After a primary series of 2 doses and 3 doses, 80.6% (95% confidence interval [CI]; 76.0-85.1%) and 95.7% (95% CI; 94.0-98.0%) of infants achieved an antibody level >= 1.0 mu g/mL, respectively. The immunogenic response to the PRP-T vaccine was acceptable after a primary series of 3 doses and also 2 doses. A reduced number of doses as a primary series could be carefully considered in Korean infants. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Haemophilus influenzae type b | ko_KR |
dc.subject | Vaccines | ko_KR |
dc.subject | Meta-analysis | ko_KR |
dc.subject | Immunity | ko_KR |
dc.title | Immunogenicity of Haemophilus influenzae Type b Conjugate Vaccines in Korean Infants: A Meta-analysis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 한서경 | - |
dc.contributor.AlternativeAuthor | 이환종 | - |
dc.contributor.AlternativeAuthor | 김경호 | - |
dc.identifier.doi | 10.3346/jkms.2010.25.1.90 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
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dc.description.tc | 3 | - |
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