Browse

Early Pulmonary Complications After Hematopoietic Stem Cell Transplantation in Pediatric Patients: Association With Cytomegalovirus Infection

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors

Lee, Ji Won; Kang, Hyoung Jin; Park, June Dong; Shin, Hee Young; Ahn, Hyo Seop

Issue Date
2009-08
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY; Vol.31 8; 545-551
Keywords
pulmonary complicationshematopoietic stein cell transplantationCMV infection
Abstract
Pulmonary complications resulting in high morbidity and mortality occur in a Substantial proportion of hematopoietic stem cell transplantation (HSCT) recipients. We investigated the incidence, causes, and risk factors of pulmonary complications, early after HSCT in pediatric patients, and patient outcomes by retrospective analysis of patients who underwent HSCT at Seoul National University Children`s Hospital between September 2003 and June 2007. A total of 145 patients were evaluated of whom 15 (10.3%) developed Pulmonary complications. Eight patients were suspected to have infection-related pulmonary complications and 7 had noninfectious causes. In a multivariate analysis of allogeneic transplantation recipients, detection of cytomegalovirus antigenemia was significantly associated with the development of both pulmonary complications and acute respiratory distress syndrome. Eleven (73.3%) of the 15 patients developed acute respiratory distress syndrome, required mechanical ventilation and eventually died. Early use of methylprednisolone in 3 patients decreased the oxygenation index. Sixteen patients died due to treatment-related complications early after HSCT, and pulmonary complications accounted for a substantial portion of the mortality. Thus, improvement of prophylaxis and management for Pulmonary complications is crucial to improve the overall outcome of HSCT. More aggressive prophylaxis and treatment of cytomegalovirus infection and judicious use of methylprednisolone at the appropriate time could be the means for such improvement.
ISSN
1077-4114
Language
English
URI
https://hdl.handle.net/10371/76993
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse