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Clinical severity of respiratory adenoviral infection by serotypes in Korean children over 17 consecutive years (1991-2007)

Cited 30 time in Web of Science Cited 32 time in Scopus
Authors
Lee, Jina; Choi, Eun Hwa; Lee, Hoan Jong
Issue Date
2010-10
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CLINICAL VIROLOGY; Vol.49 2; 115-120
Keywords
Clinical severityRisk factorsTrend analysisEpidemiologyAdenovirus types
Abstract
Background: Human adenoviruses (HAdVs) are important causes of acute respiratory tract illness in children. Objectives: To evaluate the risk factors for severe respiratory HAdV infections and the temporal change in case-severity in relation to HAdV types. Study design: From January 1991 to December 2007, respiratory HAdV infections of Korean children requiring hospitalization or an emergency room visit were included. An episode of HAdV infection requiring an intensive care unit stay, use of mechanical ventilation and/or death was designated as a severe infection. The medical records were reviewed retrospectively. Results: A total of 428 respiratory HAdV infections were included in the clinical analysis. The mean age of patients was 2.6 years. The most frequent diagnosis was a lower respiratory tract infection (312/428, 72.9%), and 44% of respiratory HAdV infections occurred in patients with underlying co-morbidities. Fifteen percent of clinical events resulted in severe HAdV infections with a case-fatality rate of 5.1%. HAdV types 7 and 8 were associated with severe infections, after adjusting for co-morbidity and the age of patients (adjusted OR 8.5 and 15.1, respectively, by a logistic regression model). The case-severity of HAdV-7 associated with lower respiratory tract infections has decreased over time, coinciding with the decreasing size of subsequent epidemics after a large outbreak (P for trend = 0.003). Conclusions: HAdV types 7 and 8 were independent risk factors for severe respiratory HAdV infections. In addition, the overall severity of HAdV-7 associated lower respiratory tract infections has shown a decreasing trend, which may reflect increasing level of herd immunity. (C) 2010 Elsevier B.V. All rights reserved.
ISSN
1386-6532
Language
English
URI
https://hdl.handle.net/10371/76997
DOI
https://doi.org/10.1016/j.jcv.2010.07.007
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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