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Role of Human Coronavirus NL63 in Hospitalized Children With Croup
DC Field | Value | Language |
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dc.contributor.author | Sung, Ji Yeon | - |
dc.contributor.author | Lee, Hoan Jong | - |
dc.contributor.author | Eun, Byung Wook | - |
dc.contributor.author | Kim, So Hee | - |
dc.contributor.author | Lee, Ju Young | - |
dc.contributor.author | Choi, Eun Hwa | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Lee, So Yeon | - |
dc.date.accessioned | 2012-06-12T04:45:14Z | - |
dc.date.available | 2012-06-12T04:45:14Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.citation | PEDIATRIC INFECTIOUS DISEASE JOURNAL; Vol.29 9; 822-826 | ko_KR |
dc.identifier.issn | 0891-3668 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76998 | - |
dc.description.abstract | Background: Human coronavirus NL63 (HCoV-NL63) has recently been implicated as a common cause of croup in children. This study was performed to evaluate viruses associated with croup in children, with an emphasis on HCoV-NL63. Methods: Nasopharyngeal aspirates were prospectively collected from 182 children hospitalized with croup at Seoul National University Bundang Hospital from January 2005 to June 2009. Multiplex reverse-transcriptase polymerase chain reaction was conducted for detection of 11 respiratory viruses, and medical records were reviewed. Results: Viruses were identified in 147 (80.8%) of the 182 croup patients. The 3 most commonly detected viruses were parainfluenza virus type 1 (PIV1) in 44 (24.2%) patients, HCoV-NL63 in 30 (16.5%) patients, and influenza A virus in 25 (13.7%) patients. Other detected viruses were rhinovirus in 22 (12.1%) patients, PIV type 3 and respiratory syncytial virus in 15 (8.2%) patients, human bocavirus in 8 (4.4%) patients, and several others in a few patients. Coinfections with >2 viruses were found in 20 (11%) patients. HCoV-NL63 was identified primarily in winter, which coincides with the peak occurrence of croup. Patients with HCoV-NL63 infection were younger than those who were positive for PIV1 (median age 13 months versus 21 months, P = 0.006) and had shorter fever duration than influenza A virus infection (median 1.5 days versus 4 days, P = 0.000). Conclusions: PIV1 and HCoV-NL63 were most commonly associated with patients who were hospitalized with croup. HCoV-NL63 is prevalent in winter and is associated with younger age and with shorter fever duration. | ko_KR |
dc.description.sponsorship | Supported by the Seoul National University Bundang Hospital Research Fund
(grant no. 02-2009-015). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | ko_KR |
dc.subject | human coronavirus NL63 | ko_KR |
dc.subject | croup | ko_KR |
dc.subject | parainfluenza virus type 1 | ko_KR |
dc.title | Role of Human Coronavirus NL63 in Hospitalized Children With Croup | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 성지연 | - |
dc.contributor.AlternativeAuthor | 이환종 | - |
dc.contributor.AlternativeAuthor | 은병욱 | - |
dc.contributor.AlternativeAuthor | 김소희 | - |
dc.contributor.AlternativeAuthor | 이소연 | - |
dc.contributor.AlternativeAuthor | 이주영 | - |
dc.contributor.AlternativeAuthor | 박경운 | - |
dc.contributor.AlternativeAuthor | 최은화 | - |
dc.identifier.doi | 10.1097/INF.0b013e3181de9c2e | - |
dc.citation.journaltitle | PEDIATRIC INFECTIOUS DISEASE JOURNAL | - |
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dc.description.tc | 5 | - |
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