Browse

Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome

Cited 46 time in Web of Science Cited 54 time in Scopus
Authors
Lee, S. H.; Yoo, K. H.; Sung, K. W.; Koo, H. H.; Kwon, M. M.; Park, B-K; Park, J. A.; Seo, J. J.; Shin, H. Y.; Ahn, H. S.; Kang, H. J.; Im, H. J.; Kim, Y. Y.; Park, H. J.; Kwon, Y. J.
Issue Date
2010-08
Publisher
NATURE PUBLISHING GROUP
Citation
BONE MARROW TRANSPLANTATION; Vol.45 8; 1287-1293
Keywords
veno-occlusive diseaselipid microspheres-containing prostaglandin E1ferritinprophylaxishematopoietic stem cell transplantation
Abstract
Four hundred and sixty-seven hematopoietic stem cell transplantations (HSCTs) (217 autologous and 250 allogeneic HSCT) were performed in 374 children at four pediatric HSCT centers in Korea from January 2005 to December 2007. Among 467 transplants, veno-occlusive disease (VOD) developed in 72 transplants (15.4%) at a median of 10 days after HSCT. Multivariate analysis showed that BU or TBI-containing regimen (P = 0.002), VOD prophylaxis without lipo-prostaglandin E1 (PGE1) (P = 0.012), number of previous HSCT (P = 0.014), and pretransplant serum ferritin (P = 0.018) were independent risk factors for developing VOD. Mean serum ferritin levels were significantly higher in HSCT with VOD (2109.6 +/- 2842.5 ng/ml) than in HSCT without VOD (1315.9 +/- 1094.4 ng/ml) (P < 0.001). The relative risk of death within 100 days of HSCT in transplants with VOD compared with transplants without VOD was 3.39 (confidence interval: 1.78-6.45). Our results suggest that lipo-PGE1 might have a protective effect against the development of VOD, and pretransplant serum ferritin could act as a risk factor for VOD. A larger prospective study is needed to confirm a possible role of lipo-PGE1 and iron chelation therapy in reducing the incidence of VOD.
ISSN
0268-3369
Language
English
URI
https://hdl.handle.net/10371/77001
DOI
https://doi.org/10.1038/bmt.2009.349
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse