S-Space College of Medicine/School of Medicine (의과대학/대학원) Pediatrics (소아과학전공) Journal Papers (저널논문_소아과학전공)
Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome
- Lee, S. H.; Yoo, K. H.; Sung, K. W.; Koo, H. H.; Kwon, M. M.; Park, B-K; Park, J. A.; Seo, J. J.; Shin, H. Y.; Ahn, H. S.; Kang, H. J.; Im, H. J.; Kim, Y. Y.; Park, H. J.; Kwon, Y. J.
- Issue Date
- NATURE PUBLISHING GROUP
- BONE MARROW TRANSPLANTATION; Vol.45 8; 1287-1293
- veno-occlusive disease; lipid microspheres-containing prostaglandin E1; ferritin; prophylaxis; hematopoietic stem cell transplantation
- Four hundred and sixty-seven hematopoietic stem cell transplantations (HSCTs) (217 autologous and 250 allogeneic HSCT) were performed in 374 children at four pediatric HSCT centers in Korea from January 2005 to December 2007. Among 467 transplants, veno-occlusive disease (VOD) developed in 72 transplants (15.4%) at a median of 10 days after HSCT. Multivariate analysis showed that BU or TBI-containing regimen (P = 0.002), VOD prophylaxis without lipo-prostaglandin E1 (PGE1) (P = 0.012), number of previous HSCT (P = 0.014), and pretransplant serum ferritin (P = 0.018) were independent risk factors for developing VOD. Mean serum ferritin levels were significantly higher in HSCT with VOD (2109.6 +/- 2842.5 ng/ml) than in HSCT without VOD (1315.9 +/- 1094.4 ng/ml) (P < 0.001). The relative risk of death within 100 days of HSCT in transplants with VOD compared with transplants without VOD was 3.39 (confidence interval: 1.78-6.45). Our results suggest that lipo-PGE1 might have a protective effect against the development of VOD, and pretransplant serum ferritin could act as a risk factor for VOD. A larger prospective study is needed to confirm a possible role of lipo-PGE1 and iron chelation therapy in reducing the incidence of VOD.
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