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Radiosurgery for brain metastasis from advanced gastric cancer

Cited 13 time in Web of Science Cited 14 time in Scopus
Authors
Han, Jung Ho; Kim, Dong Gyu; Chung, Hyun-Tai; Kim, Chae-Yong; Chung, Young Seob; Yoo, Moon-Won; Jung, Hee-Won; Kim, Baek-Hui; Paek, Sun Ha; Park, Chul-Kee
Issue Date
2010-04
Publisher
SPRINGER WIEN
Citation
ACTA NEUROCHIRURGICA; Vol.152 4; 605-610
Keywords
Brain metastasisWhole-brain radiotherapyGamma Knife radiosurgeryAdvanced gastric carcinoma
Abstract
We retrospectively evaluated the survival of patients with brain metastases from advanced gastric cancer (AGC) after radiosurgery (RS). Between 1998 and 2007, a total of 11 patients (median age, 61 years; range, 36-70) were diagnosed with brain metastasis from AGC and treated with RS. Each of five (46%) patients had two brain metastases. The median volume of the 16 lesions was 2.9 cm(3) (range, 0.1-33.8). The median marginal dose prescribed was 20 Gy (range, 10-25) at the 50% isodose line. RS was the primary treatment for brain metastases in six patients. As of February 28, 2008, eight (73%) patients had died, and three (27%) were living with stable disease. The median survival time was 17.0 +/- 3.9 months (95% CI, 9.4-24.6). The median progression-free survival time was 9.0 +/- 2.5 months (95% CI, 4.2-13.8). Patients who did not undergo WBRT died within 8 months, and the other six patients treated with WBRT at various time intervals from the diagnosis of brain metastases survived, with a median survival time of 19.0 +/- 3.4 months (95% CI, 12.4-25.6). Radiosurgery seems to be a good alternative to surgical resection for patients with brain metastases from AGC, when performed in conjunction with WBRT.
ISSN
0001-6268
Language
English
URI
https://hdl.handle.net/10371/77055
DOI
https://doi.org/10.1007/s00701-009-0554-4
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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