Publications
Detailed Information
Withdrawal of Antiepileptic Drugs after Neocortical Epilepsy Surgery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Kyung-Il | - |
dc.contributor.author | Lee, Sang Kun | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Lee, Seo-Young | - |
dc.contributor.author | Chung, Chun Kee | - |
dc.contributor.author | Lee, Jung Ju | - |
dc.contributor.author | Bae, Eun-Kee | - |
dc.date.accessioned | 2012-06-14T00:44:16Z | - |
dc.date.available | 2012-06-14T00:44:16Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | ANNALS OF NEUROLOGY; Vol.67 2; 230-238 | ko_KR |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77056 | - |
dc.description.abstract | Objective: This study investigated the prevalence of successful antiepileptic drug withdrawal and identified predictors of seizure recurrence after antiepileptic drug reduction following resectional operation for intractable neocortical epilepsy. Methods: We retrospectively assessed 223 patients (100 with neocortical temporal lobe epilepsy, 69 with frontal lobe epilepsy, 23 with parietal lobe epilepsy, 25 with occipital lobe epilepsy, and 6 with multifocal epilepsy) who underwent surgery. The mean period of observation was 84.4 months (range, 24-152 months) after surgery and 72.6 months (range, 12-138 months) after initial reduction. Clinical characteristics, magnetic resonance imaging, and surgical parameters were evaluated for their potential to predict recurrence associated with antiepileptic drug withdrawal. Results: Antiepileptic drug reduction was attempted in 147 patients (65.9%), 78 (53.1%) of whom had seizure recurrence after initial reduction. Discontinuation was achieved in 73 patients (32.7%), and 59 (80.8%) of these remained seizure free until final assessment. Multivariate analysis revealed that early drug tapering, normal magnetic resonance imaging results, seizure before reduction, and longer epilepsy duration were associated with recurrence. Finally, 27.4% of patients were seizure free without drugs, and 26.9% were seizure free with drugs. Compared with preoperative status, the number of antiepileptic drugs needed decreased in 50.7% of patients, did not change in 19.3%, and increased in 30.0% after surgery. Interpretation: The complete-cure rate of intractable neocortical epilepsy by resectional surgery was 27.4%. When patients undertake early tapering, and have normal magnetic resonance imaging results, seizure before reduction, and longer disease duration, further withdrawal should be done cautiously because of the high risk of relapse. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-LISS | ko_KR |
dc.title | Withdrawal of Antiepileptic Drugs after Neocortical Epilepsy Surgery | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박경일 | - |
dc.contributor.AlternativeAuthor | 이상건 | - |
dc.contributor.AlternativeAuthor | 추곤 | - |
dc.contributor.AlternativeAuthor | 정근화 | - |
dc.contributor.AlternativeAuthor | 배은기 | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.contributor.AlternativeAuthor | 이정주 | - |
dc.contributor.AlternativeAuthor | 이서영 | - |
dc.contributor.AlternativeAuthor | 정천기 | - |
dc.identifier.doi | 10.1002/ana.21884 | - |
dc.citation.journaltitle | ANNALS OF NEUROLOGY | - |
dc.description.citedreference | Krsek P, 2009, NEUROLOGY, V72, P217 | - |
dc.description.citedreference | Kim DW, 2009, NEUROLOGY, V72, P211 | - |
dc.description.citedreference | Lee JJ, 2008, SEIZURE-EUR J EPILEP, V17, P514, DOI 10.1016/j.seizure.2008.01.007 | - |
dc.description.citedreference | Lossius MI, 2008, EPILEPSIA, V49, P455, DOI 10.1111/j.1528-1167.2007.01323.x | - |
dc.description.citedreference | Al-Kaylani M, 2007, SEIZURE-EUR J EPILEP, V16, P95, DOI 10.1016/j.seizure.2006.10.007 | - |
dc.description.citedreference | Jeha LE, 2007, BRAIN, V130, P574, DOI 10.1093/brain/awl364 | - |
dc.description.citedreference | Tellez-Zenteno JF, 2007, BRAIN, V130, P334, DOI 10.1093/brain/awl316 | - |
dc.description.citedreference | Jeha LE, 2006, NEUROLOGY, V66, P1938 | - |
dc.description.citedreference | Yun CH, 2006, EPILEPSIA, V47, P574 | - |
dc.description.citedreference | Berg AT, 2006, EPILEPSIA, V47, P64 | - |
dc.description.citedreference | Kim YD, 2005, EPILEPSIA, V46, P251 | - |
dc.description.citedreference | Siegel AM, 2004, NEUROLOGY, V63, P2298 | - |
dc.description.citedreference | Tonini C, 2004, EPILEPSY RES, V62, P75, DOI 10.1016/j.eplepsyres.2004.08.006 | - |
dc.description.citedreference | McIntosh AM, 2004, BRAIN, V127, P2018, DOI 10.1093/brain/awh221 | - |
dc.description.citedreference | Cohen-Gadol AA, 2004, J NEUROSURG, V101, P55 | - |
dc.description.citedreference | Hader WJ, 2004, J NEUROSURG, V100, P110 | - |
dc.description.citedreference | WIEBE S, 2004, CURR NEUROL NEUROSCI, V4, P315 | - |
dc.description.citedreference | Schmidt D, 2003, EPILEPSY RES, V56, P85, DOI 10.1016/j.eplepsyres.2003.10.004 | - |
dc.description.citedreference | Wieser HG, 2003, EPILEPSY RES, V55, P211, DOI 10.1016/S0920-1211(03)00116-5 | - |
dc.description.citedreference | Bien CG, 2001, EPILEPSIA, V42, P1416 | - |
dc.description.citedreference | Kral T, 2001, CHILD NERV SYST, V17, P595 | - |
dc.description.citedreference | Hong SC, 2000, J NEUROSURG, V93, P766 | - |
dc.description.citedreference | Mosewich RK, 2000, EPILEPSIA, V41, P843 | - |
dc.description.citedreference | Schiller Y, 2000, NEUROLOGY, V54, P346 | - |
dc.description.citedreference | Mathern GW, 1999, EPILEPSIA, V40, P1740 | - |
dc.description.citedreference | Ferrier CH, 1999, J NEUROL NEUROSUR PS, V66, P350 | - |
dc.description.citedreference | Maher J, 1998, NEUROLOGY, V51, P305 | - |
dc.description.citedreference | BERG AT, 1998, EPILEPSY COMPREHENSI, P1275 | - |
dc.description.citedreference | Gilliam F, 1997, NEUROLOGY, V48, P1368 | - |
dc.description.citedreference | Zentner J, 1996, EPILEPSIA, V37, P1072 | - |
dc.description.citedreference | Spencer SS, 1996, EPILEPSIA, V37, P807 | - |
dc.description.citedreference | Greenberg MK, 1996, NEUROLOGY, V47, P600 | - |
dc.description.citedreference | LORENZO NY, 1995, EPILEPSY RES, V20, P171 | - |
dc.description.citedreference | GULDVOG B, 1994, EPILEPSIA, V35, P540 | - |
dc.description.citedreference | HAGLUND MM, 1993, NEUROSURG CLIN N AM, V4, P283 | - |
dc.description.citedreference | GULDVOG B, 1991, EPILEPSIA, V32, P477 | - |
dc.description.tc | 3 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.