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Protective Role of COMP-Ang1 in Ischemic Rat Brain
DC Field | Value | Language |
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dc.contributor.author | Shin, Hye Young | - |
dc.contributor.author | Lee, Yoon Jin | - |
dc.contributor.author | Kim, Hak Joo | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Wang, Kyu Chang | - |
dc.contributor.author | Koh, Gou Young | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Kim, Jong Hoon | - |
dc.date.accessioned | 2012-06-14T01:29:54Z | - |
dc.date.available | 2012-06-14T01:29:54Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE RESEARCH; Vol.88 5; 1052-1063 | ko_KR |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77063 | - |
dc.description.abstract | In cerebral ischemia, the induction of angiogenesis may represent a natural defense mechanism that enables the hypoxic brain to avoid progression into infarction. Angiopoietin-1 (Ang1) is known to produce non-leaky and stable blood vessel formation mainly by the Tie2 receptor. Therefore, we envisioned that the application of cartilage oligomeric matrix protein-Ang1 (COMP-Ang1), a soluble, stable, and potent form of Ang1, would promote angiogenesis and provide a protective effect following unilateral middle cerebral artery occlusion (MCAO) in rats. To this end, we employed a 2-hour-MCAO model, and treated rats with adenovirus encoding COMP-Ang1 (Ade-COMP-Ang1) or control virus encoding beta-gal (Ade-beta-gal). Time course magnetic resonance images (MRIs) revealed significantly reduced infarct volume in the rats treated with Ade-COMP-Ang1 with an improvement of post-ischemic neurological deficits compared with rats treated with Ade-beta-gal. Moreover, compared to the rats treated with Ade-beta-gal, the rats treated with Ade-COMP-Ang1 showed an increase in blood vessels, especially in the border zone adjacent to the infarction, increased number of endogenous neuronal progenitor cells in the ischemic brain, and decreased number of TUNEL-positive cells. Taken together, COMP-Ang1 reduced infarct volume and consequently attenuated post-ischemic neurological deficits through enhanced angiogenesis and increased viable cell mass of neuronal cells. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-LISS | ko_KR |
dc.subject | Blood vessels | ko_KR |
dc.subject | cerebral ischemia | ko_KR |
dc.subject | Neurogenesis | ko_KR |
dc.subject | ischaemia | ko_KR |
dc.subject | Neuroprotection | ko_KR |
dc.subject | Gene transfer | ko_KR |
dc.title | Protective Role of COMP-Ang1 in Ischemic Rat Brain | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 신혜영 | - |
dc.contributor.AlternativeAuthor | 이윤진 | - |
dc.contributor.AlternativeAuthor | 김학주 | - |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 김종훈 | - |
dc.contributor.AlternativeAuthor | 왕규창 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 고구영 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.identifier.doi | 10.1002/jnr.22274 | - |
dc.citation.journaltitle | JOURNAL OF NEUROSCIENCE RESEARCH | - |
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dc.description.tc | 4 | - |
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