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Desmopressin is an Effective Treatment for Mixed Nocturia with Nocturnal Polyuria and Decreased Nocturnal Bladder Capacity

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Lee, Hye Won; Choo, Myung-Soo; Lee, Jeong Gu; Park, Choal Hee; Lee, Jeong Zoo; Park, Won Hee; Lee, Kyu-Sung; Han, Deok Hyun; Paick, Jae-Seung
Issue Date
2010-12
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 12; 1792-1797
Keywords
Urinary BladderDeamino Arginine VasopressinNocturnal PolyuriaNocturiaHyponatremia
Abstract
To investigate the efficacy and safety of desmopressin in patients with mixed nocturia, Patients aged >= 18 yr with mixed nocturia (>= 2 voids/night and a nocturnal polyuria index [NPi] >33% and a nocturnal bladder capacity index [NBCi] >1) were recruited. The optimum dose of oral desmopressin was determined during a 3-week dose-titration period and the determined dose was maintained for 4 weeks. The efficacy was assessed by the frequency-volume charts and the sleep questionnaire. The primary endpoint was the proportion of patients with a 50% or greater reduction in the number of nocturnal voids (NV) compared with baseline. Among 103 patients enrolled, 94 (79 men and 15 women) were included in the analysis. The proportion of patients with a 50% or greater reduction in NV was 68 (72%). The mean number of NV decreased significantly (3.20 to 1.34) and the mean nocturnal urine volume, nocturia index, NPi, and NBCi decreased significantly. The mean duration of sleep until the first NV was prolonged from 118.4 +/- 44.1 to 220.3 +/- 90.7 min (P<0.001). The overall impression of patients about their quality of sleep improved. Adverse events occurred in 6 patients, including one asymptomatic hyponatremia. Desmopressin is an effective and well-tolerated treatment for mixed nocturia.
ISSN
1011-8934
Language
English
URI
http://hdl.handle.net/10371/77068
DOI
https://doi.org/10.3346/jkms.2010.25.12.1792
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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