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Characteristics and prognosis of chromophobe non-metastatic renal cell carcinoma: A multicenter study

Cited 26 time in Web of Science Cited 31 time in Scopus
Authors
Lee, Won Ki; Byun, Seok-Soo; Kim, Hyeon Hoe; Rha, Koon Ho; Sung, Gyung Tak; Lim, Jae Sung; Kwon, Tae Gyun; Jeong, Young Beom; Lee, Wan; Hwang, Tae-Kon
Issue Date
2010-11
Publisher
WILEY-BLACKWELL
Citation
INTERNATIONAL JOURNAL OF UROLOGY; Vol.17 11; 898-904
Keywords
chromophobesurvivalrenal cell carcinomapathologyconventional
Abstract
Objectives: To analyze the characteristics and the prognostic significance of chromophobe renal cell carcinomas (chRCC). Methods: Data about 2981 patients with non-metastatic renal cell carcinomas (RCC) at the time of surgery were retrospectively collected from 26 institutions between 1998 and 2008. All patients had undergone partial or radical nephrectomies. Of the 2981 patients, 2602 patients with conventional RCC (cRCC) and 148 with chRCC were studied. Clinical and pathological parameters were determined in all patients. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were assessed. Results: Patients with chRCC differed significantly from those with cRCC on the following parameters: younger age (P = 0.026), greater female ratio (P < 0.001), and larger tumor diameter (P < 0.001). Both groups were alike with respect to body mass index (P = 0.943), Eastern Cooperative Oncology Group performance status (P = 0.163), T stage (P = 0.375), and Fuhrman`s grade (P = 0.134). The 5-year RFS rates in patients with chRCC and cRCC were 82.7% and 83.3%, respectively (P = 0.762). The 5-year CSS rates in patients with chRCC and cRCC were 88.8% and 92.2%, respectively (P = 0.980). Both groups showed equivalent oncological outcomes in terms of RFS and CSS for cases stratified by T stage and Fuhrman`s grade. In multivariate analysis, the histological subtype was not retained as an independent prognostic variable (RFS: P = 0.893; CSS: P = 0.729). Conclusions: Despite being significantly different from cRCC in terms of several clinical and pathological parameters, chRCC shows equivalent oncological outcomes.
ISSN
0919-8172
Language
English
URI
https://hdl.handle.net/10371/77070
DOI
https://doi.org/10.1111/j.1442-2042.2010.02630.x
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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