Browse

Influence of IGFBP3 Gene Polymorphisms on IGFBP3 Serum Levels and the Risk of Prostate Cancer in Low-risk Korean Men

DC Field Value Language
dc.contributor.authorPark, Kwanjin-
dc.contributor.authorKim, Jeong H.-
dc.contributor.authorJeon, Hwang G.-
dc.contributor.authorByun, Seok S.-
dc.contributor.authorLee, Eunsik-
dc.date.accessioned2012-06-14T06:48:32Z-
dc.date.available2012-06-14T06:48:32Z-
dc.date.issued2010-06-
dc.identifier.citationUROLOGY; Vol.75 6;1516.e1–1516.e7ko_KR
dc.identifier.issn0090-4295-
dc.identifier.urihttps://hdl.handle.net/10371/77077-
dc.description.abstractOBJECTIVES To understand the relationship between the -202 A/C single-nucleotide polymorphism (SNP) of the insulin-like growth factor-binding protein 3 (IGFBP3) gene, IGFBP3 serum levels, and risk of prostate cancer (PCa) in a Korean population, as a potential reason for the lower incidence of PCa in the Korean population. METHODS The IGFBP3 levels were measured and the -202 A/C SNP of the IGFBP3 gene was typed for 225 PCa cases and the same number of matched controls. Linear regression analysis and unconditional logistic regression analysis were used to test for the associations between the genotypes and the circulating IGFBP3 levels and the risk of PCa, respectively. To adjust for the potential bias introduced by the hospital cohort, the result of the genotyping was compared with that of 683 community-indwelling healthy men. RESULTS Significantly lower plasma levels of IGFBP3 were noted in the PCa cases. Lower IGFBP3 plasma levels were associated with an increased number of C alleles (P < .001). Compared with the PCa cases, a lower frequency of the C allele was found in the hospital and community controls (P < .05). Compared with AA genotype, logistic regression analysis revealed an increased risk of PCa in subjects who were CC genotype (odds ratio: 2.39, 95% confidence interval: 1.05-5.48). Larger odds (odds ratio: 3.37, 95% confidence interval: 1.35-8.43) for PCa were associated with CC genotype when the analysis was confined to those who had high-risk PCa. CONCLUSIONS The results supported the protective role of -202 A/C SNP of the IGFBP3 gene against PCa in Korean men.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER SCIENCE INCko_KR
dc.titleInfluence of IGFBP3 Gene Polymorphisms on IGFBP3 Serum Levels and the Risk of Prostate Cancer in Low-risk Korean Menko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박관진-
dc.contributor.AlternativeAuthor이은식-
dc.identifier.doi10.1016/j.urology.2009.08.023-
dc.citation.journaltitleUROLOGY-
dc.description.citedreferenceRaimondi S, 2009, CARCINOGENESIS, V30, P1170, DOI 10.1093/carcin/bgp103-
dc.description.citedreferenceHernandez W, 2007, CARCINOGENESIS, V28, P2154, DOI 10.1093/carcin/bgm190-
dc.description.citedreferenceLiu B, 2007, ONCOGENE, V26, P1811, DOI 10.1038/sj.onc.1209977-
dc.description.citedreferenceLEE J, 2007, CANC CONTROL, V14, P78-
dc.description.citedreferenceQin LQ, 2007, ASIA PAC J CLIN NUTR, V16, P467-
dc.description.citedreferenceChen C, 2006, CANCER EPIDEM BIOMAR, V15, P2461, DOI 10.1158/1055-9965.EPI-06-0541-
dc.description.citedreferenceSeveri G, 2006, CANCER EPIDEM BIOMAR, V15, P1137, DOI 10.1158/1055-9965.EPI-05-0823-
dc.description.citedreferenceSilha JV, 2006, ENDOCRINOLOGY, V147, P2112, DOI 10.1210/en.2005-1270-
dc.description.citedreferenceMoon JW, 2006, INT J CANCER, V118, P353, DOI 10.1002/ijc.21339-
dc.description.citedreferenceLi L, 2005, CANCER EPIDEM BIOMAR, V14, P2462, DOI 10.1158/1055-9965.EPI-05-0531-
dc.description.citedreferenceSchildkraut JM, 2005, CANCER EPIDEM BIOMAR, V14, P403-
dc.description.citedreferenceChen C, 2005, CANCER, V103, P76, DOI 10.1002/cncr.20727-
dc.description.citedreferenceDeLellis K, 2004, CANCER EPIDEM BIOMAR, V13, P1444-
dc.description.citedreferencePeng LH, 2004, MOL ENDOCRINOL, V18, P1109, DOI 10.1210/me.2003-0344-
dc.description.citedreferenceWang LZ, 2003, CANCER RES, V63, P4407-
dc.description.citedreferenceGunnell D, 2003, BRIT J CANCER, V88, P1682, DOI 10.1038/sj.bjc.6600946-
dc.description.citedreferenceChokkalingam AP, 2001, CANCER EPIDEM BIOMAR, V10, P421-
dc.description.citedreferenceDeal C, 2001, J CLIN ENDOCR METAB, V86, P1274-
dc.description.citedreferenceVerhage BAJ, 2001, UROLOGY, V57, P97-
dc.description.citedreferenceBAXTER RC, 2001, MOL PATHOL, V54, P145-
dc.description.citedreferenceStattin P, 2000, J NATL CANCER I, V92, P1910-
dc.description.citedreferenceHarman SM, 2000, J CLIN ENDOCR METAB, V85, P4258-
dc.description.citedreferencePlatz EA, 1999, CANCER EPIDEM BIOMAR, V8, P1107-
dc.description.citedreferenceTricoli JV, 1999, UROLOGY, V54, P178-
dc.description.citedreferenceParkin DM, 1999, INT J CANCER, V80, P827-
dc.description.citedreferenceSTANFORD JL, 1999, NIH PUB-
dc.description.citedreferenceD`Amico AV, 1998, JAMA-J AM MED ASSOC, V280, P969-
dc.description.citedreferenceWolk A, 1998, J NATL CANCER I, V90, P911-
dc.description.citedreferenceSchaid DJ, 1998, AM J HUM GENET, V62, P1425-
dc.description.citedreferenceChan JM, 1998, SCIENCE, V279, P563-
dc.description.citedreferencePage WF, 1997, PROSTATE, V33, P240-
dc.description.citedreferenceHarrela M, 1996, J CLIN INVEST, V98, P2612-
dc.description.citedreferenceKAO PC, 1994, J CLIN ENDOCR METAB, V78, P310-
dc.description.citedreferenceSHIMIZU H, 1991, BRIT J CANCER, V63, P963-
dc.description.tc1-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse