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전립샘암의 병인 : Pathogenesis of Prostate Cancer

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dc.contributor.author윤철용-
dc.contributor.author변석수-
dc.date.accessioned2012-06-14T08:19:07Z-
dc.date.available2012-06-14T08:19:07Z-
dc.date.issued2010-02-
dc.identifier.citationJOURNAL OF THE KOREAN MEDICAL ASSOCIATION; Vol.53 2; 98-106ko_KR
dc.identifier.issn1975-8456-
dc.identifier.urihttps://hdl.handle.net/10371/77082-
dc.description.abstractProstate cancer is one of the most frequent cancers in Western countries and has been also one of the most rapidly increasing malignant diseases in Korean men. This disease shows diverse features in clinical course ranging from an indolent disease to a lethal one. Accordingly, underlying molecular mechanisms and genetic changes involved in the development and progression of various types of prostate cancer are very heterogeneous. Thus, investigation of pathogenesis of prostate cancer is very challenging, and, at this point of time, only a handful of molecular and genetic factors were identified as pathogenic factors for prostate cancer. Plenty of data support the strong relationship between age, race and family history and the development of prostate cancer. In addition, androgen related factors such as androgen metabolism and receptor signaling are highly correlated with tumor development and progression. Numerous genetic or epigenetic changes including gene mutation and methylation contribute to the development and progression of prostate cancer. In this article, we summarize the current understanding of the pathogenesis of prostate cancer, with a special focus on underlying genetic and epigenetic alterations.ko_KR
dc.language.isokoko_KR
dc.publisherKOREAN MEDICAL ASSOCko_KR
dc.subjectProstate cancerko_KR
dc.subjectEpigeneticsko_KR
dc.subjectPathogenesisko_KR
dc.subjectGeneko_KR
dc.subject전립샘암ko_KR
dc.subject병인ko_KR
dc.subject유전자ko_KR
dc.subject후성학ko_KR
dc.title전립샘암의 병인ko_KR
dc.title.alternativePathogenesis of Prostate Cancerko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthorYoon, Cheol-Yong-
dc.contributor.AlternativeAuthorByun, Seok-Soo-
dc.citation.journaltitleJOURNAL OF THE KOREAN MEDICAL ASSOCIATION-
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