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Epigenetic markers as promising prognosticators for bladder cancer

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dc.contributor.authorKim, Young Kyoon-
dc.contributor.authorKim, Wun-Jae-
dc.date.accessioned2012-06-15T00:59:20Z-
dc.date.available2012-06-15T00:59:20Z-
dc.date.issued2008-
dc.identifier.citationINTERNATIONAL JOURNAL OF UROLOGY; Vol.16 1; 17-22ko_KR
dc.identifier.issn0919-8172-
dc.identifier.urihttps://hdl.handle.net/10371/77097-
dc.description.abstractTransitional cell carcinomas of the urinary bladder have diverse biological and functional characteristics. Surveillance strategies for bladder cancer recurrence have historically relied on the diagnostic combination of cystoscopy and urinary cytology. However, the accuracy of both tests depends on subjective and operator-dependent interpretations of the visible findings. In contrast, promoter hypermethylation of CpG islands is strongly associated with tumor development and prognosis of bladder cancer. Detection of DNA methylation in voided urine may be feasible and more sensitive than conventional urine cytology. Ultimately, all types of urological cancers may be screened in urine using a candidate panel of hypermethylated genes. The epigenetic silencing of tumor suppressor genes is interest from a clinical point of view because it is possible to reverse epigenetic changes and restore gene function to a cell. Methylation markers might therefore be more useful than conventional molecular markers for the treatment and prevention of bladder cancer.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-BLACKWELL PUBLISHING, INCko_KR
dc.subjectbladder neoplasmsko_KR
dc.subjectprognosisko_KR
dc.subjectmarkerko_KR
dc.subjectmethylationko_KR
dc.titleEpigenetic markers as promising prognosticators for bladder cancerko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김영균-
dc.contributor.AlternativeAuthor김운재-
dc.identifier.doi10.1111/j.1442-2042.2008.02143.x-
dc.citation.journaltitleINTERNATIONAL JOURNAL OF UROLOGY-
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dc.description.tc20-
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