Publications
Detailed Information
Therapeutic Effect of Recombinant Human Epidermal Growth Factor (RhEGF) on Mucositis in Patients Undergoing Radiotherapy, With or Without Chemotherapy, for Head And Neck Cancer A Double-blind Placebo-controlled Prospective Phase 2 Multi-institutional Clinical Trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wu, Hong Gyun | - |
dc.contributor.author | Song, Si Yeol | - |
dc.contributor.author | Kim, Yeon Sil | - |
dc.contributor.author | Oh, Young Taek | - |
dc.contributor.author | Keum, Ki Chang | - |
dc.contributor.author | Lee, Sang-wook | - |
dc.contributor.author | Ahn, Yong Chan | - |
dc.contributor.author | Lee, Chang Geol | - |
dc.date.accessioned | 2012-06-15T05:35:39Z | - |
dc.date.available | 2012-06-15T05:35:39Z | - |
dc.date.issued | 2009-08-15 | - |
dc.identifier.citation | CANCER; Vol.115 16; 3699-3708 | ko_KR |
dc.identifier.issn | 0008-543X | - |
dc.identifier.uri | https://hdl.handle.net/10371/77102 | - |
dc.description.abstract | BACKGROUND: We evaluated the efficacy of topically applied human recombinant epidermal growth factor (rhEGF) for the treatment of oral mucositis induced by radiotherapy (RT), with or without chemotherapy, in patients with head and neck cancer. METHODS: Patients receiving definitive chemoradiotherapy, definitive RT, or postoperative RT to the oral cavity or oropharynx were recruited from 6 institutions and enrolled in a randomized, double-blind, placebo-controlled phase 2 trial. Patients were assigned to a placebo group or to 1 of 3 EGF-treatment groups (10, 50, or 100 mu g/mL doses, delivered in a spray, twice daily). The grade of mucositis was evaluated using the Radiation Therapy Oncology Group (RTOG) scoring criteria. Responders to EGF were defined as having an RTOG grade of 2 or lower at the fourth- or fifth-week examinations during RT, but an enduring RTOG grade 2 for 2 weeks was an exception. RESULTS: Of the 113 patients included in the study, 28 received placebo and 29 received EGF at 10 mu g/mL, 29 at 50 mu g/mL, and 27 at 100 mu g/mL. EGF significantly reduced the incidence of severe oral mucositis at the primary endpoint (a 64% response was observed with SO mu g/mL EGF vs a 37% response in the control group; P = .0246). CONCLUSIONS: The EGF oral spray may have potential benefit for oral mucositis in patients undergoing RT for head and neck cancer. Phase 3 studies are ongoing to confirm these results. Cancer 2009;115:3699-708. (C) 2009 American Cancer Society. | ko_KR |
dc.description.sponsorship | This study was supported by a grant from the National R&D
Program for Cancer Central, Ministry of Health, Welfare and Family Affairs, Republic of Korea (0620270). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | JOHN WILEY & SONS INC | ko_KR |
dc.subject | mucositis | ko_KR |
dc.subject | EGF | ko_KR |
dc.subject | radiotherapy | ko_KR |
dc.subject | head and neck cancer | ko_KR |
dc.subject | chemotherapy | ko_KR |
dc.title | Therapeutic Effect of Recombinant Human Epidermal Growth Factor (RhEGF) on Mucositis in Patients Undergoing Radiotherapy, With or Without Chemotherapy, for Head And Neck Cancer A Double-blind Placebo-controlled Prospective Phase 2 Multi-institutional Clinical Trial | ko_KR |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 우홍균 | - |
dc.contributor.AlternativeAuthor | 송시열 | - |
dc.contributor.AlternativeAuthor | 김연실 | - |
dc.contributor.AlternativeAuthor | 오영택 | - |
dc.contributor.AlternativeAuthor | 이창걸 | - |
dc.contributor.AlternativeAuthor | 금기창 | - |
dc.contributor.AlternativeAuthor | 안용찬 | - |
dc.contributor.AlternativeAuthor | 이상욱 | - |
dc.identifier.doi | 10.1002/cncr.24414 | - |
dc.citation.journaltitle | CANCER | - |
dc.description.citedreference | Lee KK, 2008, INT J RADIAT ONCOL, V71, P1230, DOI 10.1016/j.ijrobp.2008.03.041 | - |
dc.description.citedreference | Lee SW, 2007, INT J RADIAT ONCOL, V67, P1172, DOI 10.1016/j.ijrobp.2006.10.038 | - |
dc.description.citedreference | Hong JP, 2006, ANN PLAS SURG, V56, P394, DOI 10.1097/01.sap.0000198731.12407.0c | - |
dc.description.citedreference | Buentzel J, 2006, INT J RADIAT ONCOL, V64, P684, DOI 10.1016/j.ijrobp.2005.08.005 | - |
dc.description.citedreference | Fung K, 2005, INT J RADIAT ONCOL, V63, P1395, DOI 10.1016/j.ijrobp.2005.05.004 | - |
dc.description.citedreference | Masucci G, 2005, MED ONCOL, V22, P247 | - |
dc.description.citedreference | Fowler JF, 2003, RADIOTHER ONCOL, V69, P161, DOI 10.1016/S0167-8140(03)00231-7 | - |
dc.description.citedreference | Garden AS, 2003, SEMIN RADIAT ONCOL, V13, P267, DOI 10.1016/S1053-4296(03)00028-6 | - |
dc.description.citedreference | Dorr W, 2002, INT J RADIAT ONCOL, V52, P911 | - |
dc.description.citedreference | Dorr W, 2001, RADIOTHER ONCOL, V61, P223 | - |
dc.description.citedreference | Sutherland SE, 2001, INT J RADIAT ONCOL, V49, P917 | - |
dc.description.citedreference | Vokes EE, 2000, SEMIN ONCOL, V27, P34 | - |
dc.description.citedreference | Trotti A, 2000, INT J RADIAT ONCOL, V47, P1 | - |
dc.description.citedreference | Carter DL, 1999, HEAD NECK-J SCI SPEC, V21, P760 | - |
dc.description.citedreference | Plevova P, 1999, ORAL ONCOL, V35, P453 | - |
dc.description.citedreference | Kaanders JHAM, 1999, RADIOTHER ONCOL, V50, P247 | - |
dc.description.citedreference | Cengiz M, 1999, J CLIN GASTROENTEROL, V28, P40 | - |
dc.description.citedreference | Sonis ST, 1998, ORAL ONCOL, V34, P39 | - |
dc.description.citedreference | Epstein JB, 1997, ORAL ONCOL, V33, P359 | - |
dc.description.citedreference | Dische S, 1997, RADIOTHER ONCOL, V44, P123 | - |
dc.description.citedreference | Alden ME, 1996, RADIOLOGY, V201, P675 | - |
dc.description.citedreference | Lefebvre JL, 1996, J NATL CANCER I, V88, P890 | - |
dc.description.citedreference | Teo PML, 1996, BRIT J RADIOL, V69, P241 | - |
dc.description.citedreference | DORR W, 1995, RADIOTHER ONCOL, V37, P100 | - |
dc.description.citedreference | GIRDLER NM, 1995, AM J CLIN ONCOL-CANC, V18, P403 | - |
dc.description.citedreference | DORR W, 1994, INT J RADIAT BIOL, V66, P157 | - |
dc.description.citedreference | PROCACCINO F, 1994, GASTROENTEROLOGY, V107, P12 | - |
dc.description.citedreference | INO M, 1993, ACTA OTO-LARYNGOL, P126 | - |
dc.description.citedreference | WOLF GT, 1991, NEW ENGL J MED, V324, P1685 | - |
dc.description.citedreference | NOGUCHI S, 1991, AM J PHYSIOL, V260, pE620 | - |
dc.description.citedreference | BARKER G, 1991, ORAL SURG ORAL MED O, V71, P288 | - |
dc.description.citedreference | DORR W, 1991, VIRCHOWS ARCH B, V60, P287 | - |
dc.description.citedreference | CHRISTEN RD, 1990, J CLIN INVEST, V86, P1632 | - |
dc.description.citedreference | WEAVER LT, 1990, GASTROENTEROLOGY, V98, P828 | - |
dc.description.citedreference | EPSTEIN JB, 1989, INT J RADIAT ONCOL, V16, P1571 | - |
dc.description.citedreference | WATERFIELD MD, 1989, LANCET 0603, P1243 | - |
dc.description.citedreference | THESLEFF I, 1988, LIFE SCI, V43, P13 | - |
dc.description.citedreference | OLSEN PS, 1986, GUT, V27, P1443 | - |
dc.description.citedreference | KAMATA N, 1986, CANCER RES, V46, P1648 | - |
dc.description.citedreference | KIM JH, 1986, AM J CLIN ONCOL-CANC, V9, P132 | - |
dc.description.citedreference | COHEN S, 1983, CANCER, V51, P1787 | - |
dc.description.citedreference | IMAI Y, 1982, CANCER RES, V42, P4394 | - |
dc.description.citedreference | BARNES DW, 1982, J CELL BIOL, V93, P1 | - |
dc.description.citedreference | GILL GN, 1981, NATURE, V293, P305 | - |
dc.description.citedreference | PARSONS JT, 1980, INT J RADIAT ONCOL, V6, P1645 | - |
dc.description.citedreference | STEIDLER NE, 1980, ARCH ORAL BIOL, V25, P37 | - |
dc.description.citedreference | CARPENTER G, 1980, SCIENCE, V210, P198 | - |
dc.description.citedreference | GRESIK EW, 1979, AM J ANAT, V156, P83 | - |
dc.description.citedreference | HEITZ PU, 1978, GUT, V19, P408 | - |
dc.description.citedreference | GREGORY H, 1975, NATURE, V257, P325 | - |
dc.description.citedreference | SAVAGE CR, 1972, J BIOL CHEM, V247, P7612 | - |
dc.description.citedreference | COHEN S, 1962, J BIOL CHEM, V237, P1555 | - |
dc.description.tc | 9 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.