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Interstitial Fluid Pressure as a Prognostic Factor in Cervical Cancer Following Radiation Therapy
DC Field | Value | Language |
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dc.contributor.author | Yeo, Seung-Gu | - |
dc.contributor.author | Kim, Jun-Sang | - |
dc.contributor.author | Cho, Moon-June | - |
dc.contributor.author | Kim, Ki-Hwan | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.date.accessioned | 2012-06-15T05:38:46Z | - |
dc.date.available | 2012-06-15T05:38:46Z | - |
dc.date.issued | 2009-10-01 | - |
dc.identifier.citation | CLINICAL CANCER RESEARCH; Vol.15 19; 6201-6207 | ko_KR |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77103 | - |
dc.description.abstract | Purpose: To investigate tumor interstitial fluid pressure as a prognostic factor for recurrence-free survival in patients with cervical cancer following radiation therapy. Experimental Design: Tumor interstitial fluid pressure was measured in 55 cervical cancer patients who received radiation therapy between August 1998 and September 2002. Interstitial fluid pressure measurements were made before radiation therapy (pre-radiation therapy interstitial fluid pressure) and after a median of 28.8 Gy in 16 fractions (range, 25.2-30.6 Gy in 14-17 fractions) of radiation therapy (mid-radiation therapy interstitial fluid pressure), using a modified wick-in-needle technique. Median follow-up was 74 months (range, 2-118 months). The Kaplan-Meier method with the log-rank test and Cox`s proportional hazard model were used in univariate and multivariate analyses, respectively, of prognostic factors for recurrence-free survival. Results: Median pre-radiation therapy and mid-radiation therapy interstitial fluid pressure were 29.0 mm Hg (range, 4.0-93.9 mm Hg) and 20.0 mm Hg (range, -1.2 to 29.6 mm Hg), respectively (P = 0.001). Pre-radiation therapy interstitial fluid pressure was significantly higher in adenocarcinomas than squamous cell carcinomas (P = 0.028). Significant reduction of interstitial fluid pressure was noted only in patients with complete responses (P = 0.002), and mid-radiation therapy interstitial fluid pressure was significantly lower in patients with complete responses (P = 0.036). In the multivariate analysis including interstitial fluid pressures and clinical variables, pre-radiation therapy interstitial fluid pressure was an independent prognostic factor for local and distant recurrence-free survival (P = 0.001 and 0.027, respectively). Conclusions: Mid-radiation therapy interstitial fluid pressure measurement may be useful in predicting radiation therapy responses, and pre-radiation therapy interstitial fluid pressure was a significant prognostic factor for local and distant relapse-free survival in patients with cervical cancer after radiation therapy. (Clin Cancer Res 2009;15(19):6201-7) | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER ASSOC CANCER RESEARCH | ko_KR |
dc.title | Interstitial Fluid Pressure as a Prognostic Factor in Cervical Cancer Following Radiation Therapy | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 여승구 | - |
dc.contributor.AlternativeAuthor | 김준상 | - |
dc.contributor.AlternativeAuthor | 조문준 | - |
dc.contributor.AlternativeAuthor | 김기환 | - |
dc.contributor.AlternativeAuthor | 김재성 | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-09-0560 | - |
dc.citation.journaltitle | CLINICAL CANCER RESEARCH | - |
dc.description.citedreference | Fyles A, 2006, RADIOTHER ONCOL, V80, P132, DOI 10.1016/j.radonc.2006.07.014 | - |
dc.description.citedreference | Mayr NA, 2006, AM J ROENTGENOL, V187, P65, DOI 10.2214/AJR.05.0039 | - |
dc.description.citedreference | Wachsberger PR, 2005, CLIN CANCER RES, V11, P835 | - |
dc.description.citedreference | Jain RK, 2005, SCIENCE, V307, P58, DOI 10.1126/science.1104819 | - |
dc.description.citedreference | Heldin CH, 2004, NAT REV CANCER, V4, P806, DOI 10.1038/nrc1456 | - |
dc.description.citedreference | Wachsberger P, 2004, HEMATOL ONCOL CLIN N, V18, P1039, DOI 10.1016/j.hoc.2004.06.007 | - |
dc.description.citedreference | Milosevic A, 2004, SEMIN RADIAT ONCOL, V14, P249, DOI 10.1016/j.semradonc.2004.04.006 | - |
dc.description.citedreference | Eifel PJ, 2004, J CLIN ONCOL, V22, P872, DOI 10.1200/JCO.2004.07.197 | - |
dc.description.citedreference | Willett CG, 2004, NAT MED, V10, P145, DOI 10.1038/nm988 | - |
dc.description.citedreference | Thorpe PE, 2004, CLIN CANCER RES, V10, P415 | - |
dc.description.citedreference | RECOULESARCHE A, 2004, GYNECOL OBSTET FERTI, V32, P116 | - |
dc.description.citedreference | Salnikov AV, 2003, FASEB J, V17, P1756, DOI 10.1096/fj.02-1201fje | - |
dc.description.citedreference | Wachsberger P, 2003, CLIN CANCER RES, V9, P1957 | - |
dc.description.citedreference | Gorski DH, 2003, CANCER RES, V63, P308 | - |
dc.description.citedreference | Siemann DW, 2002, INT J RADIAT ONCOL, V53, P164 | - |
dc.description.citedreference | Milosevic M, 2001, AM J CLIN ONCOL-CANC, V24, P516 | - |
dc.description.citedreference | Milosevic M, 2001, CANCER RES, V61, P6400 | - |
dc.description.citedreference | Santin AD, 1999, OBSTET GYNECOL, V94, P78 | - |
dc.description.citedreference | Keys HM, 1999, NEW ENGL J MED, V340, P1154 | - |
dc.description.citedreference | Milosevic MF, 1998, CANCER, V82, P2418 | - |
dc.description.citedreference | Tokumo K, 1998, GYNECOL ONCOL, V68, P38 | - |
dc.description.citedreference | Ferrara N, 1997, ENDOCR REV, V18, P4 | - |
dc.description.citedreference | Boucher Y, 1996, CANCER RES, V56, P4264 | - |
dc.description.citedreference | Nieto FJ, 1996, AM J EPIDEMIOL, V143, P1059 | - |
dc.description.citedreference | EIFEL PJ, 1995, GYNECOL ONCOL, V59, P38 | - |
dc.description.citedreference | GUIDI AJ, 1995, J NATL CANCER I, V87, P1237 | - |
dc.description.citedreference | LESS JR, 1992, CANCER RES, V52, P6371 | - |
dc.description.citedreference | BOUCHER Y, 1992, CANCER RES, V52, P5110 | - |
dc.description.citedreference | GUTMANN R, 1992, CANCER RES, V52, P1993 | - |
dc.description.citedreference | BOUCHER Y, 1991, CANCER RES, V51, P6691 | - |
dc.description.citedreference | ROH HD, 1991, CANCER RES, V51, P6695 | - |
dc.description.citedreference | BOUCHER Y, 1990, CANCER RES, V50, P4478 | - |
dc.description.citedreference | BAXTER LT, 1989, MICROVASC RES, V37, P77 | - |
dc.description.citedreference | JAIN RK, 1988, CANCER RES, V48, P7022 | - |
dc.description.citedreference | JAIN RK, 1987, CANCER RES, V47, P3039 | - |
dc.description.citedreference | MILLER AB, 1981, CANCER, V47, P207 | - |
dc.description.tc | 5 | - |
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