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HDAC Inhibitor-Mediated Radiosensitization in Human Carcinoma Cells: A General Phenomenon?

Cited 22 time in Web of Science Cited 23 time in Scopus
Authors
Kim, In Ah; Kim, Il Han; Kim, Hak Jae; Chie, Eui Kyu; Kim, Jae-Sung
Issue Date
2010-05
Publisher
JAPAN RADIATION RESEARCH SOC
Citation
JOURNAL OF RADIATION RESEARCH; Vol.51 3; 257-263
Keywords
Histone deacetylase inhibitorATMp53Trichostatin ARadiosensitization
Abstract
Historic deacetylase inhibitors (HDIs) have attracted considerable attention for anticancer therapy strategy. including radiosensitization Regarding a potential application of HDI as a radiosensitizer in the treatment of solid tumors, an important question is whether treatment efficacy would be Influenced by intrinsic differences between cancer cells, such as different histologic origin and status of ATM or p53. First we have observed the in vitro radiosensitization by Trichostatin A (TSA) on the broad spectrum of human tumor cell lines having different histologic origin such as HCT116 adenocarcinoma of colon. A549 adenocarcinoma of lung. HN-3 squamous cell carcinoma of head/neck, and HeLa squamous cacinoma of uterine cervix, using clonogenic assay. Next, we have systematically assessed the radiosensitization on the cell lines having different ATM or p53 status. We found that pretreatment of HDI consistently resulted in radiosensitization of all cell lines tested, though the sensitizer enhancement ratio of individual cell lines was variable We also observed that TSA-mediated radiosensitization was clearly influenced by p53 and ATM status of cells tested. The data presented here indicate that HDI enhances the radiation induced cell killing in the various cancer cells having intrinsic differences and may serve as a general strategy for enhancing tumor cell radiosensitivity These results have potential implications for the clinical utility of HDI in increasing the anticancer efficacy of radiation
ISSN
0449-3060
Language
English
URI
https://hdl.handle.net/10371/77105
DOI
https://doi.org/10.1269/jrr.09115
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College of Medicine/School of Medicine (의과대학/대학원)Radiation Oncology (방사선종양학전공)Journal Papers (저널논문_방사선종양학전공)
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