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한국인 유방 관상피내암의 재발에 영향을 미치는 임상병리학적 특성과 인자
Clinicopathological Characteristics and Factors Affecting Recurrence of Ductal Carcinoma In Situ in Korean Women

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Authors
김지선; 문형곤; 안수경; 민준원; 신희철; 김한석; 염차경; 하성환; 지의규; 한원식; 노동영
Issue Date
2010-12
Publisher
KOREAN BREAST CANCER SOC
Citation
JOURNAL OF BREAST CANCER; Vol.13 4; 392-397
Keywords
AgeBreast neoplasmsRecurrenceRadiotherapyDuctal carcinoma in situ나이유방신생물관상피내암방사선치료재발
Abstract
Purpose: As breast cancer screening becomes more popular in Korea, incidence of ductal carcinoma in situ (DCIS) of breast has increased to more than 10% of all breast cancer diagnosed. We aimed to show the clinicopathological characteristics and factors affecting recurrence of DCIS in Korean women. Methods: We retrospectively reviewed 152 DCIS patients who underwent breast conserving surgery in Seoul National University Hospital between January 1995 and December 2005. Results: Mean age at diagnosis was 46.7 years (24 to 66 years). Mean follow up duration of the patients was 73.82 months (0.80 to 168.43 months). Recurrence of disease occurred in 19 (12.5%) patients: 2 in contralateral breast, 15 in ipsilateral breast, and 2 in axilla. One patient showed ipsilateral breast recur after excision of axillary metastasis. Eight (42.11%) of all recurrence was infiltrating ductal carcinoma and one of them showed bone metastasis during follow up. In an multivariate analysis of factors affecting recurrence, younger age at diagnosis and omission of radiotherapy had significant association with recurrence (p=0.005 and p=0.002, respectively). However, tumor size (p=0.862), microinvasion (p=0.988), histologic grade (p=0.157), estrogen receptor status (p=0.401) and resection margin status (p=0.112) were not significantly correlated with recurrence. There was no breast cancer associated mortality. Conclusion: In this study, we found that the younger age at diagnosis and omission of adjuvant radiotherapy are independent predictors of recurrence in Korean DCIS patients.
ISSN
1738-6756
Language
Korean
URI
https://hdl.handle.net/10371/77107
DOI
https://doi.org/10.4048/jbc.2010.13.4.392
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College of Medicine/School of Medicine (의과대학/대학원)Radiation Oncology (방사선종양학전공)Journal Papers (저널논문_방사선종양학전공)
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