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Clinical characteristics, prognosis, and seropositivity to the anti-aquaporin-4 antibody in Korean patients with longitudinally extensive transverse myelitis

Cited 17 time in Web of Science Cited 18 time in Scopus
Authors
Kim, Su Hyun; Kim, Sung Min; Vincent, Angela; Ahn, Suk Won; Park, Kyung Seok; Lee, Kwang Woo; Sung, Jung Joon; Hong, Yoon Ho
Issue Date
2010-06
Publisher
SPRINGER HEIDELBERG
Citation
JOURNAL OF NEUROLOGY; Vol.257 6; 920-925
Keywords
MyelitisNeuromyelitis opticaMultiple sclerosisAnti-aquaporin-4 antibody
Abstract
Longitudinally extensive transverse myelitis (LETM) is a syndrome with extensive spinal cord lesions spanning three or more vertebral segments on spinal cord MRI. Although many reports have indicated that LETM is a characteristic feature of neuoromyelitis optica (NMO) in Western countries, the clinical characteristics and risk for development of NMO in Korean patients with LETM is not clear. We retrospectively investigated the clinical, laboratory, radiological features, and prognosis of Korean patients with a first-ever episode of idiopathic LETM. Patients were classified into four subgroups, depending on their clinical course: monophasic LETM, recurrent LETM, NMO, and classic multiple sclerosis (MS). We compared various clinical, laboratory, and radiological features between groups. Of 20 patients with first-ever LETM, 15 (75%) were men, and 13 (65%) experienced clinical relapse over a mean follow-up period of 58 months. Three of 20 patients (two with NMO, one with recurrent myelitis) were seropositive for anti-AQP4 antibodies. The predominance of men in the monophasic and recurrent LETM groups compared to the NMO group was remarkable. In conclusion, Korean patients with LETM are predominantly male and have low seropositivity for anti-AQP4 antibody, which distinguishes them from LETM patients in Western countries. Patients with LETM and seropositivity for anti-AQP4 antibody have a high risk of relapse. The male predominance and the relatively low seropositive rate for anti-AQP4 suggests that rather than being a limited form of NMO, recurrent LETM is a new clinical entity in Koreans.
ISSN
0340-5354
Language
English
URI
http://hdl.handle.net/10371/77120
DOI
https://doi.org/10.1007/s00415-009-5438-2
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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