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Risk of "silent stroke" in patients older than 60 years: risk assessment and clinical perspectives

Cited 25 time in Web of Science Cited 0 time in Scopus
Authors
Lim, Jae-Sung; Kwon, Hyung-Min
Issue Date
2010
Publisher
DOVE MEDICAL PRESS LTD
Citation
CLINICAL INTERVENTIONS IN AGING; Vol.5 ; 239-251
Keywords
silent brain infarctiontreatmentelderlyrisk factors
Abstract
With the increasing size of the elderly population and evolving imaging technology, silent brain infarction (SBI) has garnered attention from both the public and the physicians. Over 20% of the elderly exhibit SBI, and the prevalence of SBI increases steadily with age, ie, 30%-40% in those older than 70 years. Well-known cardiovascular risk factors such as hypertension has been identified as a risk factor of SBI (odds ratio [OR] = 3.47) Besides this, blood pressure (BP) reactivity to mental stress, morning BP surges, and orthostatic BP changes have been demonstrated to contribute to the presence of SBI. Further, a metabolic syndrome not only as a whole syndrome (OR = 2.18) but also as individual components could have an influence on SBI. Increased C-reactive protein and interleukin-6, coronary artery disease, body mass index, and alcohol consumption have also been associated with SBI. The ORs and - possible mechanisms have been discussed in this article. Overt stroke, dementia, depression, and aspiration pneumonia were all associated with SBI. (overt stroke: hazard ratio [HR] = 1.9, 95% confidence interval [CI]: 1.2-2.8; dementia: HR = 2.26, 95% CI: 1.09-4.70). We also looked into their close relationship with SBI in this review.
ISSN
1176-9092
Language
English
URI
https://hdl.handle.net/10371/77122
DOI
https://doi.org/10.2147/CIA.S7382
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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