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Two-Year Follow-Up on the Effect of Unilateral Subthalamic Deep Brain Stimulation in Highly Asymmetric Parkinson`s Disease

Cited 27 time in Web of Science Cited 28 time in Scopus
Issue Date
2009-02-15
Publisher
WILEY-LISS
Citation
MOVEMENT DISORDERS; Vol.24 3; 329-335
Keywords
Parkinson`s diseasedeep brain stimulationunilateral subthalamic stimulationasymmetry
Abstract
Although bilateral subthalamic deep brain stimulation (STN DBS) provides greater relief From the symptoms of Parkinson`s disease (PD) than unilateral STN DBS, it has been suggested that unilateral STN DBS may be a reasonable treatment option in selected patients, especially those with highly asymmetric PD. In previous studies on the effect of unilateral STN DBS, the asymmetry of PD symptoms was not prominent and the mean follow-up durations were only 3 to 12 months. In this Study, we report Our findings in a series of 8 patients with highly asymmetric PD who were treated with unilateral STN DBS and were followed for 24 months. Serial changes in Unified Parkinson`s Disease Rating Scale (UPDRS) motor score and subscores in the ipsilateral, contra-lateral, and axial body parts were analyzed. Unilateral STN DBS improved the UPDRS motor score and the contralateral subscores in the on-medication state for 5 nonfluctuating patients and in the off-medication state for 3 fluctuating patients. However, the ipsilateral subscore progressively worsened and reversed asymmetry became difficult to manage, which led to compromised medication and stimulator adjustment. At 24 months, all the patients were considering the second-side Surgery. Out, results Suggest that bilateral STN DBS should be considered even in highly asymmetric PD. (C) 2008 Movement Disorder Society
ISSN
0885-3185
Language
English
URI
https://hdl.handle.net/10371/77128
DOI
https://doi.org/10.1002/mds.22211
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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