S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
Olfactory Identification Deficits in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Cited 3 time in Web of Science Cited 6 time in Scopus
- Issue Date
- EUROPEAN NEUROLOGY; Vol.64 5; 280-285
- Olfactory identification ; Olfaction ; Frontotemporal lobe
- Background/Aims Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited angiopathy caused by mutations of the Notch 3 gene Olfactory identification deficits are present in a number of neurodegenerative disorders However, olfaction has not been investigated in CADASIL The aim of the present study was to assess olfactory identification in CADASIL and to determine whether there is an association between olfactory identification and the frontotemporal lobe Methods Twenty-seven patients and 27 control subjects had an olfactory identification test and neuropsychological testing Brain MRIs were obtained from 25 patients Involvement of frontal white matter, anterior temporal white matter and the external capsule were measured Results Olfactory identification scores were lower in CADASIL patients than in healthy comparison subjects The Mini-Mental Status Examination (MMSE) and semantic Controlled Oral Word Association Test (COWAT) were also affected In CADASIL patients, olfactory identification scores correlated with MMSE, COWAT scores and Scheltens` scores from frontal white matter The tendency for an association between olfactory identification scores and Scheltens scores from anterior temporal white matter was also observed Conclusion Our findings suggest that olfactory identification deficits may be a sensitive indicator of frontotemporal dysfunction in CADASIL Copyright (C) 2010 S Karger AG Basel
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