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Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice

Cited 12 time in Web of Science Cited 15 time in Scopus
Authors
Pyo, Kyoung-Ho; Jung, Bong-Kwang; Chai, Jong-Yil; Shin, Eun-Hee
Issue Date
2010-06
Publisher
KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI
Citation
KOREAN JOURNAL OF PARASITOLOGY; Vol.48 2; 171-174
Keywords
lysate antigenCD31sarcoma-180Toxoplasma gondiianti-tumorigenic effect
Abstract
The anti-tumorigenic effects of Toxoplasma gondii (RH) antigens were studied in a murine sarcoma-180 tumor model. To determine the anti-tumor effects, the reduction in tumor size and expression of CD31 (an angiogenesis marker in the tumor tissue) were examined after injection of BALB/c mice with T. gondii lysate antigen (TLA) or formalin-fixed, proliferation-inhibited, T. gondii tachyzoites. Tumors were successfully produced by an intradermal injection of sarcoma-180 cells with plain Matrigel in the mid-backs of mice. After injection with TLA or formalin-fixed T. gondii tachyzoites, the increase in tumor size and weight nearly stopped while tumor growth continued in control mice that were injected with PBS. CD31 expression in TLA-treated or formalin-fixed T. gondii-injected mice was lower than the control mice. Accordingly, the present study shows that the treatment of mice with formalin-fixed T. gondii or TLA in the murine sarcoma-180 tumor model results in a decrease of both tumor size and CD31 expression.
ISSN
0023-4001
Language
English
URI
https://hdl.handle.net/10371/77340
DOI
https://doi.org/10.3347/kjp.2010.48.2.171
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College of Medicine/School of Medicine (의과대학/대학원)Parasitology and Tropical Medicine (기생충학전공)Journal Papers (저널논문_기생충학전공)
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