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High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Chung, Goh Eun | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Myung, Sun Jung | - |
dc.contributor.author | Lee, Jeong-Hoon | - |
dc.contributor.author | Lee, Soo-Mi | - |
dc.contributor.author | Hwang, Seung Yong | - |
dc.contributor.author | Kim, Chung Yong | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.contributor.author | Kim, Seung-Jun | - |
dc.contributor.author | Lee, Sung-Hee | - |
dc.date.accessioned | 2012-06-25T05:04:23Z | - |
dc.date.available | 2012-06-25T05:04:23Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | ONCOLOGY REPORTS; Vol.23 1; 113-119 | ko_KR |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://hdl.handle.net/10371/77381 | - |
dc.description.abstract | MicroRNAs (miRNA) have recently been implicated in carcinogenesis and tumor progression. Hepatocellular carcinoma (HCC) is well known for frequent relapses following curative resection. We attempted to identify the miRNAs associated with HCC recurrence. We analyzed miRNA expression profiles in 25 pairs of HCC and adjacent non-tumor liver tissues from HCC patients using miRNA microarray. Out of 449 miRNAs assayed, we identified seven miRNAs associated with HCC recurrence. In particular, the highest ranked miR-15b was negatively correlated with recurrence. MiR-15b inhibitor transfection increased HCC cell proliferation and inhibited TRAIL-induced apoptosis, while miR-15b precursor transfection decreased proliferation and enhanced apoptosis. Bcl-w was identified as a target molecule regulated by miR-15b. These results indicate that miR-15b expression in HCC tissues may predict a low risk of HCC recurrence. In addition, the modulation of miR-15b expression may be useful as an apoptosis-sensitizing strategy for HCC treatment. | ko_KR |
dc.description.sponsorship | This study was supported by the Seoul National University
Hospital Research Fund (#03-2006-019) and the Korean Foundation of Liver Research (2008) and the Korea Health 21 R&D Project (#0412-CR01-0704-0001). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPANDIDOS PUBL LTD | ko_KR |
dc.subject | miR-15b | ko_KR |
dc.subject | Bcl-w | ko_KR |
dc.subject | apoptosis | ko_KR |
dc.subject | recurrence | ko_KR |
dc.subject | hepatocellular carcinoma | ko_KR |
dc.title | High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정고은 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 명선정 | - |
dc.contributor.AlternativeAuthor | 이정훈 | - |
dc.contributor.AlternativeAuthor | 이성희 | - |
dc.contributor.AlternativeAuthor | 이수미 | - |
dc.contributor.AlternativeAuthor | 김승준 | - |
dc.contributor.AlternativeAuthor | 황승용 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.contributor.AlternativeAuthor | 김청용 | - |
dc.identifier.doi | 10.3892/or_00000612 | - |
dc.citation.journaltitle | ONCOLOGY REPORTS | - |
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dc.description.tc | 10 | - |
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