S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
The impact of insulin sensitisers on lung function in patients with chronic obstructive pulmonary disease and diabetes
- Kim, H. J.; Lee, J. Y.; Jung, H. S.; Kim, D-K.; Yim, J-J.; Yoo, C-G.; Kim, Y. W.; Shim, Y-S.; Lee, C-H.; Han, S. K.; Chung, H. S.; Yang, S-C.; Lee, S-M.
- Issue Date
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE; Vol.14 3; 362-367
- insulin sensitiser; diabetes; insulin resistance; lung function; chronic obstructive pulmonary disease
- SETTING: It has been reported that diabetes mellitus (DM) is associated with poor pulmonary function, which could be explained by insulin resistance. OBJECTIVE: To evaluate whether insulin sensitisers (ISs) have beneficial effects on lung function in patients with chronic obstructive pulmonary disease (COPD) and DM. DESIGN: This retrospective study included patients with both COPD and DM who attended Seoul National University Hospital for treatment between 1 January 2000 and 31 August 2007. They were treated with inhalers for COPD and oral hypoglycaemia agents, including ISs or insulin, for DM. The primary outcome was a change in lung function in spirometric examinations. RESULTS: Among 61 patients enrolled, 32 were in the no IS group, while 29 were in the IS group. On multivariable regression analysis, the IS group showed a significantly greater change in forced vital capacity (FVC) than the no IS group (adjusted beta-coefficient 131.9, 95%CI 8.5-255.4, P = 0.04). CONCLUSIONS: Treatment with an IS was independently associated with improvements in FVC in patients with both COPD and DM, compared with treatment without IS.
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