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Increased Circulating Endothelial Microparticles and Carotid Atherosclerosis in Obstructive Sleep Apnea
DC Field | Value | Language |
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dc.contributor.author | Yun, Chang-Ho | - |
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Kim, So-Hyun | - |
dc.contributor.author | Park, Hee-Kwon | - |
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Roh, Jae-Kyu | - |
dc.contributor.author | Lee, Sang-Kun | - |
dc.contributor.author | Kim, Hwan-Cheol | - |
dc.contributor.author | Ji, Ki-Hwan | - |
dc.date.accessioned | 2012-06-25T05:34:06Z | - |
dc.date.available | 2012-06-25T05:34:06Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | JOURNAL OF CLINICAL NEUROLOGY; Vol.6 2; 89-98 | ko_KR |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77389 | - |
dc.description.abstract | Background and Purpose Endothelial impairment is a linking mechanism between obstructive sleep apnea (USA) and cardiovascular diseases Profiles of endothelial micropanicles (EMPs) and endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment The aims of this study were to measure the levels of EMI`s and progenitor cells in USA, determine the correlations between these factors and USA severity and the deuce of atherosclerosis, and document any changes in these factors after therapy Methods Subjects with (n=82) and without (n=22) OSA were recruited prospectively We measured the number of colony-forming units (CM) in cell cultuie as the endothelial progenitor cell index, and the number of EMPs using flow cytometry with CD31 [platelet endothelial cell adhesion molecule (PECAM)], CD42 (platelet glycoprotem), annexm V, and CD62E (E-selectin) antibodies at baseline and Act 4-6 weeks of continuous positive airway pressure (CPA P) therapy Carotid int ima-media thickness (IMT) was regarded as a marker of atherosclerosis Results The levels of PECAM(+)CD42(-) (p<0 001). PECAM(+)annexin V(+) (p<0 001), and E-selectin(+) micropamcles (p=0 001) were higher in USA subjects than in non-USA subjects The number of CRJ did not differ between the two groups OSA severity independently predicted the levels of PECAM(+)CD42(-) (p=0 02) and PECA(+)annexin V(+) (p=0 004) Carotid IMT was correlated with USA severity (p<0 001), PECAM(+)CD42: (p=0 03), and PECAM(+)annexin (p=0 01) Neither USA severity nor carotid IMT was correlated with either the number of CFI) or E-selectin(+) CPAP therapy decreased the occurrence of E-selecte (p<0 001) in 21 of the USA subjects, but had no effect on the other micioparticles of the number CFU Conclusions USA led to the overproduction of EMI`s, which moderately correlated with USA seventy and the degree of atherosclerosis, and partly responded to therapy The endothelial impairment might contribute to future cardiovascular events J Clin Neurol 2010;6`89-98 | ko_KR |
dc.description.sponsorship | This research was supported by the Stem Cell Research Center of the
21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea (#SC4120). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN NEUROLOGICAL ASSOC | ko_KR |
dc.subject | atherosclerosis | ko_KR |
dc.subject | colony-forming units assay | ko_KR |
dc.subject | continuous positive airway pressure | ko_KR |
dc.subject | progenitor cells | ko_KR |
dc.subject | endothelium | ko_KR |
dc.title | Increased Circulating Endothelial Microparticles and Carotid Atherosclerosis in Obstructive Sleep Apnea | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 윤창호 | - |
dc.contributor.AlternativeAuthor | 정근화 | - |
dc.contributor.AlternativeAuthor | 추곤 | - |
dc.contributor.AlternativeAuthor | 김소현 | - |
dc.contributor.AlternativeAuthor | 지기환 | - |
dc.contributor.AlternativeAuthor | 박희권 | - |
dc.contributor.AlternativeAuthor | 김환철 | - |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 이상군 | - |
dc.contributor.AlternativeAuthor | 노재규 | - |
dc.identifier.doi | 10.3988/jcn.2010.6.2.89 | - |
dc.citation.journaltitle | JOURNAL OF CLINICAL NEUROLOGY | - |
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dc.description.tc | 6 | - |
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