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The impact of nutritional deficit on mortality of in-patients with pulmonary tuberculosis

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Authors
Kim, H-J.; Lee, C-H.; Shin, S.; Lee, J. H.; Chung, H. S.; Shim, Y-S.; Kim, D. K.; Han, S. K.; Kim, Y. W.
Issue Date
2010-01
Publisher
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Citation
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE; Vol.14 1; 79-85
Keywords
malnutritiontuberculosisprognosis
Abstract
SETTING: A metropolitan governmental medical centre, Seoul, Republic of Korea. OBJECTIVE: To elucidate the impact of the nutritional deficit assessed by the Nutritional Risk Score (NRS) on the outcomes of in-patients with pulmonary tuberculosis (PTB). DESIGN: All hospitalised patients with microbiologically confirmed PTB were enrolled. A four-point NRS included low body mass index (<18.5 kg/m(2)), hypoalbuminacmia (<30.0 g/l), hypocholesterolaemia (<2.33 mmol/l) and severe lymphocytopaenia (<7 x 10(5) cells/l). The primary outcome was overall in-hospital mortality. The degree of radiographical resolution after anti-tuberculosis treatment was also evaluated. RESULTS: In a total of 156 patients, the male to female ratio was 1.6:1. The overall mortality was 13.5% and tuberculosis-specific fatality was 3.9%. Predisposing factors and high NRS (>= 3 points) were independent risk factors for in-hospital death after adjusting for the severity of PTB. High NRS (OR = 16.8, P < 0.001) and predisposing factors (OR = 5.4, P = 0.032) were independent risk factors for 30-day survival. The NRS was not associated with radiographic improvement. CONCLUSION: Regardless of disease severity, the high NRS was a significant negative predictor among inpatients with PTB; this finding should therefore be considered in the management of PTB despite the current era of effective anti-tuberculosis chemotherapy.
ISSN
1027-3719
Language
English
URI
https://hdl.handle.net/10371/77392
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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